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Werdnig-Hoffman disease Spinal muscular atrophy of infants. This is one of the causes of the FLOPPY INFANT SYNDROME. There is profound loss of muscle TONE, absence of reflexes, weakness of the muscles of respiration and twitching of the tongue. The diagnosis can be confirmed by muscle BIOPSY. There is no known treatment and the outlook is grave. (Guido Werdnig, 1844–1919, Austrian neurologist; and Johann Hoffman, 1857–1919, German neurologist).