Weibel-Palade bodies | definition of Weibel-Palade bodies by Medical dictionary
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Wei·bel-Pa·lade bod·ies (vī'bel pah-lah'dā),
rod-shaped bundles of tubular elements seen by electron microscopy in vascular endothelial cells; contain von Willebrand factor
Palade, George Emil, Romanian-U.S. cell biologist and Nobel laureate, 1912–.
Palade granule - a granule of ribonucleoprotein, the site of protein synthesis from aminoacyl-tRNAs as directed by mRNAs. Synonym(s): ribosome
- see under Weibel
Weibel, Ewald R., Swiss physician, 1929–.
Weibel-Palade bodies - rod-shaped bundles of microtubules seen by electron microscopy in vascular endothelial cells.
References in periodicals archive
It may be either secreted constitutively, or stored in Weibel-Palade bodies
in the endothelial cells or [alpha]-granules of platelets for later secretion.
(6) Electron microscopy will occasionally reveal rod-shaped, microtubulated Weibel-Palade bodies
, (10) but again, this finding may not be particularly reliable, as only 1 of 13 specimens demonstrated this structure in one series.
The von Willebrand factor normally stored in the Weibel-Palade bodies
in endothelial cells is found in the form of abnormal high-molecular-weight multimers in the plasma.