GIF

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macrophage migration inhibitory factor

A 25-kD proinflammatory lymphokine, produced by T cells in response to antigenic stimulus, which inhibits macrophage migration.

Gene
MMIF is encoded by MIF on chromosome 22q11.23.

Activities
Cell-mediated immunity, inflammation and regulation of macrophage function in host defence by suppressing the anti-inflammatory effects of glucocorticoids.
 
Mechanism
Increases intracellular cAMP, polymerises microtubules, stops macrophage progression.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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