In the PMU clinical trial, the target is for ketogenic diet to achieve the so-called 'Warburg effect
,' where cancer cells are prevented from using glycolysis in order to produce the organic chemical ATP (Adenosine triphosphate) needed in the multiplication of cancer cells.
TYME-18, like SM-88, was designed to target a physiological result of the Warburg Effect
, the acidic tumor microenvironment, and has demonstrated potent responses with a well-tolerated safety profile within a pre-clinical cancer model.
Respiration on glucose results in a switch from aerobic to fermentative metabolism - equivalent to the Warburg effect
in cancer cells - in this case converting the pyruvate product of glycolysis into ethanol rather than lactate.
South Florida, discussed cancer metabolism, the Warburg Effect
, and the
When this reprogramming involves a transition to aerobic glycolysis, it is commonly referred to as the Warburg effect
. As with all cells, energy in the form of ATP is derived from glucose.
Historically, the "Warburg effect
" has been the most widely accepted hypothesis for energy metabolism in cancer cells .
Lactic acidosis in malignancies can also result from underperfusion of wide burden tumor or increased rate of aerobic glycolysis by neoplastic cells (Warburg effect
As we well know, the "Warburg effect
" is the main theory of the energy metabolism in cancer cells.
Tumor cells have been found to have increased lactate production, as they primarily utilize aerobic glycolysis, which is also known as Warburg effect
Activation of Canonical Wnt Signaling Induces Aerobic Glycolysis or Warburg Effect
The pathophysiology of type B lactic acidosis from malignancy is believed to be multifactorial including altered lactate metabolism from liver and kidney dysfunction and lactate production by cancer cells because of tumor cell overproduction of growth factors promoting glycolysis even under aerobic conditions, termed the Warburg effect
There is an intriguing recent theoretical framework that could explain the protective action of VEGF-B on a systems level, involving the inverse Warburg effect