warfarin

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warfarin

 [wor´fah-rin]
a synthetic coumarinanticoagulant, usually used as the sodium salt; administered orally or intravenously. It is also used as a rodenticide, causing fatal hemorrhaging in any mammal that consumes a sufficient dose, including humans.

war·fa·rin

(wōr'fă-rin),
An anticoagulant with the same actions as dicumarol; also used as a rodenticide; also available as the potassium salt, with the same actions and uses.

warfarin

/war·fa·rin/ (wor´fah-rin) a synthetic coumarinanticoagulant administered as the sodium salt; it is also used as a rodenticide, causing fatal hemorrhaging in any mammal consuming a sufficient dose.

warfarin

(wôr′fər-ĭn)
n.
A white crystalline compound, C19H16O4, that inhibits production of prothrombin and is used in the form of its sodium salt as an anticoagulant drug and as a rodenticide.

warfarin

An anticoagulant that inhibits synthesis of liver-dependent coagulation factors (the prothrombin complex, factors II, VII, IX and X), which are formed by gamma-carboxylation of precursor proteins.
 
Indications
Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute myocardial infarction.

Monitoring
Warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 seconds; its activity is increased by phenylbutazone, clofibrate (by outcompeting with warfarin for plasma-protein binding sites and decreased by barbiturates, which stimulate hepatic metabolism).

warfarin

Coumadin Hematology An anticoagulant that inhibits synthesis of liver-dependent coagulation factors–the prothrombin complex, factors II, VII, IX and X, which are formed by γ-carboxylation of precursor proteins Indications Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute MI; warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 secs; its activity is ↑ by phenylbutazone, clofibrate–by outcompeting with warfarin for plasma protein binding sites and ↓ by barbiturates, which stimulate hepatic metabolism. See Superwarfarin. Cf Heparin.

war·fa·rin

(wōr'fă-rin)
An anticoagulant and rodenticide.

warfarin

An ANTICOAGULANT drug used to prevent blood from clotting in the blood vessels. The drug is on the WHO official list. A brand name is Marevan.

Warfarin

A drug given to control the formation of blood clots. The PT test can be used to monitor patients being treated with warfarin.

Warfarin,

Wisconsin Alumni Research Foundation (WARF).
Warfarin - oral anticoagulant, named for the foundation.

war·fa·rin

(wōr'fă-rin)
Anticoagulant with same actions as dicumarol.

warfarin

a coumarin compound used as an anticoagulant in humans and as a rodenticide, with serious toxicity implications for all species. It is readily absorbed from the intestinal tract and acts to inhibit the reduction of oxidized vitamin K, resulting in a depletion of active vitamin K that is required for carboxylation of coagulation factors VII, IX, X and II.
Accidental poisoning in all species causes massive, spontaneous hemorrhage and death due to anemia. Less severe cases often show pulmonary hemorrhage. In pigs it is the legs that are affected preferentially and in dogs hemorrhage into the anterior mediastinum and lungs is common. Vitamin K is the specific antidote.

Patient discussion about warfarin

Q. how medications effect me side effects warfarin,s effect what does I and R mean i have my I and R each week, what is it,s function..........

A. It depends what the heart condition is but probably not. Not being on warfarin may increase your risk of stroke. Most importantly you need to address this wuestion with the doctor that prescribe the warfarin to you.

More discussions about warfarin
References in periodicals archive ?
On Tuesday, August 3, a full bench of the Lahore High Court allowed Amir Yar Waran to contest by-polls by dismissing an appeal against the acceptance of his nomination papers.
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In addition, the company said Warfarin is the most prescribed blood thinning medication in North America and is known under the brand names of Coumadin, Jantoven, Marevan and Waran.
WAPDA recently began constructing Waran Canal System, its integral component serving Federally Administered Tribal Area.
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Another PPP MNA, Amir Yar Waran, also resigned over the same issue.
Jegathes waran Muraleetharan, also known as Muralee Tharan, of Beechwood Drive, Newtown, Powys, and Jeyatheswaran Vythyatharan, also known as Vithy Tharan, of Crescent Gardens, Newtown, both deny conspiring to support the banned Sri Lankan organisation.
The ceremony was attended by MPA Khalid Mahmood Jajja, District President PML-N MNA Makhdoom Ali Hassan Gillani, MPA Kazim Peerzada, MPA Mian Shoaib Awaisi, MPA Khalid Waran, MPA Qazi Adnan Farid, MPA Afzal gill, Secretary Information PML-N Punjab Samiullah Chaudhry and 60 members of district council and 14 newly elected Chairmen of the Bahawalpur city.
Mansoor was arrested, along with-In Charge Rabita Committee Kaiful Waran and two others, from Nine Zero on Midnight raid and remained in the Rangers detention till they produced him before the judicial magistrate.