Waldenstrom macroglobulinemia


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Wal·den·ström mac·ro·glob·u·lin·e·mi·a

(vahld'ĕn-strum),
macroglobulinemia occurring in old people, characterized by proliferation of cells resembling lymphocytes or plasma cells in the bone marrow, anemia, increased sedimentation rate, and hyperglobulinemia with a narrow peak in γ-globulin or β2-globulin at about 19 S units. The spleen, liver, or lymph nodes are often enlarged with frequent purpura or mucosal bleeding.

Wal·den·ström mac·ro·glob·u·li·ne·mi·a

(vahl'den-strem mak'rō-glob'yū-li-nē'mē-ă)
Macroglobulinemia occurring in old people, characterized by proliferation of cells resembling lymphocytes or plasma cells in the bone marrow, anemia, an increased sedimentation rate, and hyperglobulinemia with a narrow peak in γ-globulin or β2-globulin at about 19 S units. The spleen, liver, and lymph nodes are often enlarged, and there is frequently purpura or mucosal bleeding.

Waldenström,

Jan G., Swedish physician, 1906–.
Waldenström macroglobulinemia - Synonym(s): hyperglobulinemic purpura; Waldenström purpura; Waldenström syndrome
Waldenström purpura - Synonym(s): Waldenström macroglobulinemia
Waldenström syndrome - Synonym(s): Waldenström macroglobulinemia
Waldenström test - a test for porphyrin in the urine.
References in periodicals archive ?
North America is expected to be the dominant market in the global Waldenstrom macroglobulinemia market owing to high prevalence of the disease and better availability of medical resources in the region.
Ramaiya, "Drug-related pneumonitis during mammalian target of rapamycin inhibitor therapy: radiographic pattern-based approach in Waldenstrom macroglobulinemia as a Paradigm," Oncologist, vol.
Rigacci et al., "Rituximab and subcutaneous 2-chloro-2'-deoxyadenosine combination treatment for patients with Waldenstrom macroglobulinemia: clinical and biologic results of a phase II multicenter study," Journal of Clinical Oncology, vol.
Case 2 was an 88-year-old man with a clinical history of Waldenstrom macroglobulinemia who was undergoing treatment with thalidomide.
[sup][23] Waldenstrom macroglobulinemia is the most common cause of HVS followed by multiple myeloma.
Thus, a diagnosis of synchronous metastatic PAA with post-treatment changes and lymphoplasmacytic lymphoma/ Waldenstrom macroglobulinemia (LPL/WM) was rendered.
This patient had Waldenstrom macroglobulinemia (IgM kappa, 1280 mg/dL).
Recently, it was shown that perifosine leads to significant inhibition of proliferation and induction of apoptosis in Waldenstrom macroglobulinemia cells in vitro [47].
For example, a certain ratio of IgM molecules is a signature of a type of cancer called Waldenstrom macroglobulinemia.
AL-type amyloidosis can occur alone and it can be associated with lymphoproliferative disorders such as multiple myeloma or Waldenstrom macroglobulinemia. In our patient, immunoglobulin light-chain immunohistochemistry was negative, as was flow cytometry.
Approximately 10-15 % of patients with myeloma or Waldenstrom macroglobulinemia develop systemic AL.
population and has long been thought to be a precursor of serious diseases, such as multiple myeloma, primary amyloidosis, and Waldenstrom macroglobulinemia. Among 17,398 samples tested, the presence or absence of MGUS, 605 cases of MGUS were identified.