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* NK: Not Known; ** EF: Ejection Fraction Table 2: Review of cases of congestive cardiac failure reported in clinical trials with bortezomib in multiple myeloma, Waldenstrom's Macroglobulinemia and plasma cell leukaemia.
Cutaneous Waldenstrom's macroglobulinemia with "deck-chair" sign treated with cyclophosphamide.
This patient presented to our hemodialysis program in the autumn of 2007, with a diagnosis of Waldenstrom's Macroglobulinemia. Her initial treatments were fraught with numerous reverse TMP alarms, to the point where the dialysis machine was changed three times in one run alone.
We report the unusual case of a 72-year-old man who developed acute and extensive necrosis of the nasal skin and soft-tissue envelope while undergoing chemotherapy for Waldenstrom's macroglobulinemia, a lymphoproliferative disorder.
"The results of early clinical trials at Stanford University Medical Center suggest that personalized active immunotherapy may induce long-term remission and improve survival in NHL patients, which leads us to believe this treatment method may be useful in other B-cell malignancies," said Richard Furman, M.D., head of CLL and Waldenstrom's Macroglobulinemia program at Weill Medical College of Cornell University in New York.
Immunoglobulins (paraproteins) -- Elevated in plasma cell dyscrasia such as multiple myeloma and Waldenstrom's macroglobulinemia. Lactic Acid Dehydrogenase Isoenzyme -- LD is an enzyme found in all normal individuals.
That's because Schaible has a rare cancer called Waldenstrom's macroglobulinemia. In short, WM is a type of blood and bone marrow cancer that has caused his immune system to rage out of control, leaving him literally on his deathbed more than once.
Usually, large quantities of monoclonal components are present in the serum of patients with multiple myeloma or Waldenstrom's macroglobulinemia. Small quantities of monoclonal components in serum may signify light chain disease, a B-lymphocytic lymphoma or leukemia, amyloid AL (amyloidosis associated with immunoglobulin light chains), a neuropathy, or the predisposition to develop a malignant plasma cell/B-lymphocyte proliferative disorder in a patient with no currently evident clinical problem (monoclonal gammopathy of undetermined significance-MGUS).
* Patients with dysproteinemia (e.g., hemoglobinopathy, gout, Waldenstrom's Macroglobulinemia).
This includes the use of ibrutinib in combination with obinutuzumab in adult patients with previously untreated chronic lymphocytic leukaemia (CLL) and the use of ibrutinib plus rituximab for the treatment of adult patients with Waldenstrom's macroglobulinemia (WM).