Waldenström's macroglobulinaemia

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Waldenström's macroglobulinaemia

A rare disease of elderly people in which a MONOCLONAL immunoglobulin, IgM, is present in excessive quantities in the blood. This is caused by a cancerous overgrowth of B LYMPHOCYTES in the bone marrow. The condition progresses to immune deficiency. Treatment is by PLASMAPHERESIS and the use of the drug CHLORAMBUCIL. (Jan Waldenström, Swedish physician, b. 1906).
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NICE had recently rejected the use of Imbruvica for patients with Waldenstrom's macroglobulinaemia - a rare type of slow growing non-Hodgkin's lymphoma - due to what the committee determined to be a lack of cost-effective evidence and uncertainty concerning other subsets.
Examples of causative diseases are leukaemia and Waldenstrom's macroglobulinaemia.
Waldenstrom's macroglobulinaemia and IgM monoclonal gammopathy of undetermined significance: emerging understanding of a potential precursor condition.
Samples from patients with previous diagnoses of myeloma, Waldenstrom's macroglobulinaemia, and lymphoma were excluded.
Earlier this year, Marie Brown, from Reading, was diagnosed with Waldenstrom's Macroglobulinaemia, which affects only five people in a million in the UK each year.