Waldenström's macroglobulinaemia

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Waldenström's macroglobulinaemia

A rare disease of elderly people in which a MONOCLONAL immunoglobulin, IgM, is present in excessive quantities in the blood. This is caused by a cancerous overgrowth of B LYMPHOCYTES in the bone marrow. The condition progresses to immune deficiency. Treatment is by PLASMAPHERESIS and the use of the drug CHLORAMBUCIL. (Jan Waldenström, Swedish physician, b. 1906).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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NICE had recently rejected the use of Imbruvica for patients with Waldenstrom's macroglobulinaemia - a rare type of slow growing non-Hodgkin's lymphoma - due to what the committee determined to be a lack of cost-effective evidence and uncertainty concerning other subsets.
Hingorani, "Bilateral simultaneous central retinal vein occlusion secondary to hyperviscosity in Waldenstrom's macroglobulinaemia," Eye, vol.
Examples of causative diseases are leukaemia and Waldenstrom's macroglobulinaemia. The fundus appearance is usually one of scattered blot haemorrhages (Figure 6).
The leaflet states: In very rare cases gammopathy, in particular type IgM (Waldenstrom's macroglobulinaemia), may cause unreliable results.
Samples from patients with previous diagnoses of myeloma, Waldenstrom's macroglobulinaemia, and lymphoma were excluded.