Waardenburg's syndrome


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Related to Waardenburg's syndrome: Waardenburg syndrome type 1, Waardenburg syndrome type 2

Waardenburg's syndrome

 [vahr´den-bergz]
a hereditary disorder, transmitted as an autosomal dominant trait, characterized by wide bridge of the nose due to lateral displacement of the inner canthi and puncta; pigmentary disturbances, including white forelock, heterochromia iridis, white eyelashes, and leukoderma; and sometimes cochlear hearing loss.
References in periodicals archive ?
[1] Waardenburg's syndrome is classified as one of two types, according to the presence (type I) or absence (type II) of dystopia canthorum.
Our search of the literature found only one previous study that investigated the use of DPOAEs in Waardenburg's syndrome. [10] In this article, we describe our study of Waardenburg's syndrome in 23 patients from 11 families.
One such disorder is Waardenburg's syndrome, a pigmentation and hearing disorder linked to mutations in the [HuP2 gene (SN: 5/2/92, p.296).
Two independent groups of researchers have found that people with a pigmentation and hearing disorder called Waardenburg's syndrome bear mutations in a gene thought to direct a critical phase of early embryonic development.