Objective: To detect the expression of CD133, E-cadherin and WWOX in colorectal cancer, analyze the correlations and pathological significance of the biomarkers.
Pathologic specimens were retrieved for immunohistochemical examination of the expressions of CD133, WWOX and E-cadherin.
Iancu et al., "WWOX
and p53 dysregulation synergize to drive the development of osteosarcoma," Cancer Research, vol.
Pospiech et al., "The role of WWOX
tumor suppressor gene in the regulation of EMT process via regulation of CDH1-ZEB1-VIM expression in endometrial cancer," International Journal of Oncology, vol.
miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX
16q deletion is another common event, seen in 35% of myeloma cases, and contains the tumour suppressor genes CYLD and WWOX .
Walker et al., "Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma," Blood, vol.
Identification of IGF1, SLC4A4, WWOX
, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.
Comparative genomic hybridization studies have identified deletions of the fragile site tumor suppressors WWOX
(44) Several genes important in the pathogenesis of pancreatic cancer such as APC, (45) TSLC/IGSF4, (46) SOCS-1, (47) cyclin D2, (48) RASSF1A, (49) WWOX
, (50) RUNX3, (51) CDH13, (52) DUSP6, (53) HHIP, (54) and SLC5A8 (55) undergo aberrant methylation, leading to reduced expression or loss of expression.