WWOX

WWOX

A gene on chromosome 16q23.3-q24.1 that encodes a putative oxidoreductase, which acts as a tumour suppressor and plays a role in apoptosis, as well as in TGFB1 signalling and TGFB1-mediated cell death. WWOX may act synergistically with p53/TP53 to control genotoxic stress-induced cell death, and may play a role in tumour necrosis factor (TNF)-mediated cell death. It inhibits Wnt signalling, and is required for normal bone development.
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References in periodicals archive ?
Objective: To detect the expression of CD133, E-cadherin and WWOX in colorectal cancer, analyze the correlations and pathological significance of the biomarkers.
Pathologic specimens were retrieved for immunohistochemical examination of the expressions of CD133, WWOX and E-cadherin.
Iancu et al., "WWOX and p53 dysregulation synergize to drive the development of osteosarcoma," Cancer Research, vol.
Pospiech et al., "The role of WWOX tumor suppressor gene in the regulation of EMT process via regulation of CDH1-ZEB1-VIM expression in endometrial cancer," International Journal of Oncology, vol.
miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene.
16q deletion is another common event, seen in 35% of myeloma cases, and contains the tumour suppressor genes CYLD and WWOX [57].
Walker et al., "Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma," Blood, vol.
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.
Comparative genomic hybridization studies have identified deletions of the fragile site tumor suppressors WWOX and FHIT.
(44) Several genes important in the pathogenesis of pancreatic cancer such as APC, (45) TSLC/IGSF4, (46) SOCS-1, (47) cyclin D2, (48) RASSF1A, (49) WWOX, (50) RUNX3, (51) CDH13, (52) DUSP6, (53) HHIP, (54) and SLC5A8 (55) undergo aberrant methylation, leading to reduced expression or loss of expression.