SAV1

(redirected from WW45)

SAV1

A gene on chromosome 14q13-q23 that encodes a key regulator of the Hippo signalling pathway. SAV1 plays a pivotal role in controlling organ size during embryogenesis and tumour suppression by restricting proliferation and promoting apoptosis, resulting in cell cycle exit and terminal differentiation in developing epithelial tissues. It is ubiquitously expressed in adult tissues, especially in the pancreas, aorta and interventricular septum.
References in periodicals archive ?
A series of recent studies have demonstrated that MST1, MST2, Sav1 (also known as WW45), and YAP genes are important for growth control and tumorigenesis in the liver [14].
Some components of the Hippo pathway are highly conserved in mammals such as MST1/2 (the Hippo homolog), WW45 (the Sav homolog; also called Sav), Lats1/2 (the Wts homolog), Mps one binder (Mob1) (the Mats homolog), YAP and its paralog TAZ (both are Yki homologs) [19], and Mer (the Mer homolog; also called Neurofibromatosis factor 2 (NF2)), while others are in a lesser degree such as FRMD6 (the Ex homolog) and FAT4 (the FAT homolog).
Chung, "Retrotransposon-specific DNA hypomethylation and two-step loss-of-imprinting during WW45 haploinsufficiency-induced hepatocarcinogenesis," Biochemical and Biophysical Research Communications, vol.