Werner syndrome

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Wer·ner syn·drome

(wĕr'nĕr), [MIM*277700]
a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.

Wer·ner syn·drome

(wĕr'nĕr), [MIM*277700]
a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.
Farlex Partner Medical Dictionary © Farlex 2012

Werner syndrome

(vĕr′nər) or

Werner's syndrome

(-nərz)
n.
An autosomal recessive disorder characterized by short stature and the appearance of premature aging after puberty, with early development of conditions such as cataracts, cardiovascular disease, osteoporosis, and malignancies.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Werner syndrome

A rare autosomal recessive progeroid syndrome (OMIM:277700) characterised by premature onset of multiple age-related disorders, including atherosclerosis, cancer, type-2 diabetes, ocular cataracts, osteoporosis, and death by age 47, often due to myocardial infarction.

Molecular pathology
Defects of WRN, which encodes a DNA helicase responsible for maintaining genomic integrity, cause Werner syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Wer·ner syn·drome

(ver'ner sin'drōm)
A premature aging disorder consisting of sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Werner,

Otto, German physician, 1879-1936.
Werner disease - hereditary disorder characterized by premature aging. Synonym(s): progeria adultorum; Werner syndrome
Werner syndrome - Synonym(s): Werner disease
Medical Eponyms © Farlex 2012
References in periodicals archive ?
However, WRN and SRP had mainly additive and dominance effects, respectively (Table 6).
The Salk researchers discovered that deletion of the WRN gene leads to heterochromatin disorganization, pointing to an important role for the WRN protein in maintaining heterochromatin.
In the present study, we found that acrolein induced cellular senescence accompanied by activation of the p53-p21 pathway and proteasome-mediated WRN protein degradation in normal human lung fibroblasts (NHLF).
"WRN Broadcast prides itself on working closely with both our clients and technology partners to make sure of a first-class service performance and this contract with CSC Media is a perfect example of this," said Dave Travis, Chief Technology Officer, WRN Broadcast.
Listeners can enjoy all of WRN's programming free of charge all in one place anytime by visiting http://www.waterlogg.com.
ed wrn es ad ur Speaking to the Daily Record ahead of a speech to the Scottish Labour conference today, Miliband vowed he would re-set the free market revolution unleashed by Thatcher.
Oribello brothers, one of three WSC champions, is also in the cast along with Vikings Cobra, AS Phoenix WRN, Anac-IP, LYR Gamefarms, FFG Archers, AAO HitCock, EP Rooster Ville GF-BAN, EP Roosterville ESJ, Jade Resort, Pleasantville MS, Ika Diego RT 114, Binangonan Hatchet, JU Tiffany, SJC 8-Cock International and Spartans Mahakam Tres.
New computer-driven research from Willis Research Network (WRN) and the National Oceanic and Atmospheric Administration (NOAA) Geophysical Fluid Dynamics Laboratory shows storms in the coming century will be more severe but less frequent, which may keep the level of damage at the historical level.
It is caused by null mutations at WRN locus, which codes for a member of RecQ family of DNA helicases.6-9,11 The disease is associated with excessive synthesis of collagen type I and III which is dependent on elevated messenger RNA(mRNA) levels.6 The locus of Werner Syndrome has been found on the short arm of chromosome 8 in both Japanese and non Japanes.5,7,11 Fibroblasts isolated from WS patients exhibit genomic instability, increased sensitivity to specific DNA damaging agents, slow proliferation, lengthened S-phase, and accelerated replicative senescence.5,7,16
Caiff fy wrn ei falu'n dipiau mn cyn ei luchio i'r coed nid nepell.
Western Copper and Gold Corporation (TSX:WRN) (NYSE Amex: WRN), a Vancouver-based exploration and development company, has started a preliminary front end engineering and design study to evaluate technology options for a liquefied natural gas process facility.