WWOX

(redirected from WOX1)

WWOX

A gene on chromosome 16q23.3-q24.1 that encodes a putative oxidoreductase, which acts as a tumour suppressor and plays a role in apoptosis, as well as in TGFB1 signalling and TGFB1-mediated cell death. WWOX may act synergistically with p53/TP53 to control genotoxic stress-induced cell death, and may play a role in tumour necrosis factor (TNF)-mediated cell death. It inhibits Wnt signalling, and is required for normal bone development.
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References in periodicals archive ?
At the boundary between adaxial and abaxial tissues, the FIL/YAB3 and KAN, respectively, up- and downregulate the WOX1 and WOX3 genes that specify redundantly lateral lamina outgrowth and leaf margin cell fate [98].
hypopitys bracts and floral organs is under the control of conserved mechanisms (Figure 7), with the exception of the absence of transcripts PHB and PHV (HD-ZIPIII), WOX1 and WOX3 (homeodomain protein), and AS2 (LBD domain transcription factor).