WOSCOPS


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WOSCOPS

 Cardiology A trial–West of Scotland Coronary Prevention Study–of the effect of pravastatin on M&M–risk of CHD, malignancy and other outcome data–in men with hypercholesterolemia. See Lipid-lowering therapy, Pravastatin. Cf MAAS, PLAC I, PLAC II, 4S–Scandanavian Simvastatin Survival Study.
References in periodicals archive ?
At that point, WOSCOPS leaders advised study participants' primary care physicians to seriously consider putting their patients on long-term statin therapy.
Disclosures: WOSCOPS was sponsored by Bristol-Myers Squibb.
Data source: The study population included a combined sample of nondiabetic participants in five large-scale trials: ASCOT-LLA, JUPITER, WOSCOPS, MEGA, and AFCAPS/TexCAPS.
(26-31) 1he Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/ TexCAPS), the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA), and the West of Scotland Coronary Prevention Study (WOSCOPS) are of particular interest because they demonstrated significant reduction in the risk of developing a first cardiac event in patients with normal to moderately high LDL-C and other CHD risk factors.
TABLE 1 6 trials showed reduced cardiovascular morbidity and mortality after lowering LDL levels STUDY N TYPE POPULATION AFCAPS/ 6605 R, DB, PC Primary TexCAP (11) prevention WOSCOPS (12) 6595 R, DB, PC Primary prevention 4S (13) 4444 R, DB, PC Secondary prevention LIPID (14) 9014 R, DB, PC Secondary prevention HHS (15) 4081 R, DB, PC Primary prevention LRC-CPPT (16) 3806 R, DB, PC Primary prevention DURATION LDL STUDY INTERVENTION (YRS) REDUC.
The West of Scotland Coronary Prevention Study (WOSCOPS) showed us that the more components of metabolic syndrome a patient fulfills, the more likely that patient is to experience a nonfatal myocardial infarction or to receive a new diagnosis of diabetes.
On the other hand, CRP was not a significant predictor of risk in a multivariable model for men of the West of Scotland Coronary Prevention Study (WOSCOPS) who had coronary events (nonfatal MI, death from coronary heart disease, or coronary revascularization) vs controls (19).
The West of Scotland Coronary Prevention Study (WOSCOPS) showed us that the more elements of metabolic syndrome a patient fulfills, the more likely he or she is to have a nonfatal MI or to receive a new diagnosis of diabetes.
Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS).
Earlier support for Lp-PLA2 as a predictor of coronary heart disease came 2.5 years ago in a secondary analysis of the landmark West of Scotland Coronary Prevention Study (WOSCOPS).
The 5-year West of Scotland study (WOSCOPS) showed that a 26% reduction in LDL-C (from a mean of 192 to 142 mg/dL) using pravastatin 40 mg per day reduced the risk of either nonfatal myocardial infarction (MI) or coronary heart disease (CHD) death (number needed to treat [NNT] = 42; relative risk [RR] = 31; 95% confidence interval [CI],17 - 43).
A recent analysis of data from the West of Scotland Coronary Prevention Study (WOSCOPS) indicated another inflammation marker, phospholipase A2 (PLA2), actually had a much stronger relationship to future cardiovascular events than did CRP, although PLA2 testing is not widely available at this time.