For WOSCOPS participants who got a 20% drop in LDL during 5 years of pravastatin from a baseline of 190 mg/dL, as was typical, the number of patients who needed to be treated (NNT) for 5 years to prevent one cardiovascular hospital admission over a 20-year period was six.
White said, but the key to why the legacy effect was seen in WOSCOPS despite the use of pravastatin--a less-potent statin--but not to date in other statin trials may lie in the fact that WOSCOPS was a primary prevention study and its participants had the youngest mean age of all the major statin trials.
Packard, was the WOSCOPS finding that the long-term benefits of 5 years of pravastatin were independent of age at treatment.
Asked why in the aftermath of the strongly positive 5-year results of WOSCOPS only 31% of patients in each treatment arm were on long-term statin therapy, he replied that 20 years ago in Scotland there really was no push for primary prevention.
While the WOSCOPS and CARE trials were designed somewhat
CARE and WOSCOPS are important landmark studies that assessed the
WOSCOPS, a five-year randomized study of 6,595 male patients
The association between increased risk of coronary events and the Arg variant of the KIF6 Trp719Arg polymorphism in both CARE and WOSCOPS was independent of traditional CHD risk factors, which was also true for the other studies mentioned in this press release.
The genetic association studies were performed among 2,715 patients of the CARE trial and among 1,561 patients of a nested case-control study of the WOSCOPS trial.
The WOSCOPS study was led by Professor James Shepherd.
The WOSCOPS study was led by Professor James Shepherd, Department of Biochemistry, University of Glasgow and Royal Infirmary.
The genetic association studies were performed with samples from the male subjects of the CARE trial (2,523 men) and with samples from the all-male WOSCOPS trial (1,562 participants in a nested case control study).