Women’s International Study of Long Duration Oestrogen after Menopause. A trial that examined the effects of hormone replacement therapy (HRT) prescribed for the first time many years after menopause
Conclusion No benefit of late-onset therapy; more cases of angina, heart attack, sudden coronary death and blood clots in women receiving HRT compared to the placebo group. The rates of stroke, breast and other cancers, fractures and overall deaths were not significantly different
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However, he said, the definitive word on this issue will not be available until the results are available--in 6 to 8 years--from the Women's Health Initiative study (in the United States) and the WISDOM Trial (in the United Kingdom).