Women's Health Initiative

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A 15-year, $628 million project involving
(1) An observational study of the health habits and medical history of ±100,000 women
(2) A randomised controlled clinical trial of HRT in ±65,500 postmenopausal women between age 50 and 79
(3) A prevention study to improve healthy behaviours in women of all ethnic and socioeconomic backgrounds

Women's Health Initiative

A 15-yr, $628 million project involving

1. An observational study of the health habits and medical Hx of ±100,000 ♀.

2. A randomized controlled clinical trial of HRT in ±65,500 postmenopausal ♀ between age 50–79.

3. A prevention study to improve healthy behaviors in ♀ of all ethnic and socioeconomic backgrounds ☎ 1.800.54-WOMEN.

Women's Health Initiative

WHI

A 15-year study of the most common causes of death and disability in postmenopausal women. Website: http://www.nhlbi.nih.gov/whi/background.htm.

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References in periodicals archive ?

In contrast, WHI participants were older (median age 63 years) and a majority (64%-82%) were >10 years postmenopausal.

Menopausal Hormone Therapy and Cardiovascular Disease: Unraveling the Role of Age and Time Since Menopause Onset

Now, with 18 years of cumulative follow-up data available (intervention and extended postintervention phases), the WHI investigators present all-cause and cause-specific mortality outcomes from the 2 HT trials.

Did long-term follow-up of WHI participants reveal any mortality increase among women who received HT?

The final analysis on HRT use from the WHI study led investigators to reaffirm their earlier conclusion that HRT is not recommended for the prevention of chronic disease--but they also found that HRT is a reasonable treatment option for the short-term management of menopausal symptoms in some women.

Hormone replacement therapy: consider pros and cons carefully: for younger postmenopausal women in good overall health, the benefits may outweigh the risks of HRT

A decade later, the WHI results have turned out to be more complex than they appeared.

Health for her: getting it right

failures to maintain an effective written conflicts of interest policy, and inadequate recording of the kinds of service or activity carried out by WHI in which a conflict of interest had arisen or may arise

FCA fines and restricts W H Ireland Limited for market abuse risks

The greatest risk was seen in breast cancer patients who at WHI enrollment were current smokers with an additional cardiovascular risk factor.

Heart disease likely killer of older breast cancer patients

This was always a faulty foundation for a study because the average age of menopause is 51 and the WHI had already studied more than 5,000 women in their 50s--and found no such benefits.

Keeps on keeping on

That is what turned on the light bulb for Cheung, who used the WHI data for this study.

Menopause experience links to kidney disease

The average age of the original WHI study group was 63--a decade older than most women taking HRT.

Risks and benefits of hormone replacement therapy, revisited: an update on the Women's Health Initiative study, which in 2002 changed the landscape of hormone replacement therapy

As emphasised throughout the first report, [6] the WHI trial was not designed to test the diet-heart hypothesis.

Noakes misses the point

The use of estrogen therapy (ET) has been on a steady decline since 2002, when the Women's Health Initiative (WHI) halted its trial of estrogen plus progestin because of adverse events, which sent shockwaves among women and the medical community.