WDR5

WDR5

A gene on chromosome 9q34 that encodes a member of the WD-repeat protein family, which are involved in various cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. WDR5 contributes to histone modification and may regulate osteoblast differentiation.
References in periodicals archive ?
WDR5 recognizes histone 3 molecules that are methylated at lysine 4 and allows the methyltransferase in the TrxG complex to bind to this region and add another methyl group; thus, WDR5 is an essential regulator of global H3K4 trimethylation (Wysocka et al.
Dou and her team also have published on another protein involved in DNA transcription, called WDR5, that places tags that are important during transcription.
Trimethylation of H3K4 involves a sequential event from the initial recruitment of a methyl transferase complex, including a methyltransferase, MLL, and WDR5 protein scaffold, which in turn mediates dimethylation to trimethylation conversion of histone H3 at K4 (Dou et al.