The WDR11 gene product partners EMX1, a homeodomain transcription factor involved in the development of olfactory neurons.
WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome.
WDR11. The WDR11 gene, on chromosome 10q26, encodes for a 1224 amino acid protein, originally identified as a potential tumor suppressor in human glioblastoma cells .
Layman, "The role of CHD7 and the newly identified WDR11 gene in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome," Molecular and Cellular Endocrinology, vol.
Malaj et al., "A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells," Oncogene, vol.
To date, at least 17 genes have been associated with KS and these include KAL1, FGFR1, PROK2, PROKR2, FGF8, HS6ST1, CHD7, WDR11
, SEMA3A, FGF17, IL17RD, DUSP6, SPRY4, FLRT3, NELF, FEZF1, and CCDC141 (3).