WDHA syndrome

Ver·ner-Mor·ri·son syn·drome

(ver'nĕr mor'i-sŏn),

watery diarrhea, hypokalemia, and achlorhydria associated with secretion of vasoactive intestinal polypeptide by a pancreatic islet-cell tumor in the absence of gastric hypersecretion.

Synonym(s): WDHA syndrome

Ver·ner-Mor·ri·son syn·drome

(ver'nĕr mor'i-sŏn),

watery diarrhea, hypokalemia, and achlorhydria associated with secretion of vasoactive intestinal polypeptide by a pancreatic islet-cell tumor in the absence of gastric hypersecretion.

Synonym(s): WDHA syndrome

Any of a number of clinical conditions characterised by watery diarrhoea, decreased K+, hypotension and dehydration caused by neuroendocrine tumours of the pancreas, most commonly VIPoma

WDHA syndrome

Watery diarrhea-hypokalemia-achlorhydria syndrome, Verner-Morrison syndrome, pancreatic 'cholera' A condition caused by ↑ serum VIP, caused by a VIPoma, a pancreatic islet cell tumor–¹⁄₂ are malignant Clinical Profuse watery diarrhea, dehydration, hypotension, shock, episodic flushing Lab Achlorhydria, ↑ or ↓ glucose, ↓ K+, ↑ Ca2+; WDHA in children is associated with ganglioneuromas

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References in periodicals archive ?

Vasoactive intestinal polypeptide secreting tumour (VIPoma) is an extremely rare NET, causing the syndrome of watery diarrhoea, hypokalaemia, and achlorhydria (WDHA syndrome), or the Verner-Morrison syndrome, named after its discoverers.

Paediatric VIPoma: A Jamboree of Electrolytes/Pediatrik VIPoma: Elektrolit Karmasasi

* VIPoma: It is vasoactive intestinal peptide secreting tumors occur as WDHA syndrome: Watery Diarrhoea, Hypokalaemia and Achlorhydria.

A case report: pancreatic neuroendocrine tumor

In adults, the majority of WDHA syndrome arises from pancreatic islet cell adenoma and hyperplasia (2, 3).

Conclusively, childhood WDHA syndrome is a picture of secretory diarrhea, hypokalemia and hypochloremia.

Vasoactive intestinal peptide releasing tumor which caused to chronic watery diarrhea and hypokalemia