WD40 Domain

A family of amino acid repeats found in proteins with a wide range of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing, cytoskeleton assembly and cell cycle control
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LRRK2, one of the genes related to autosomal dominant form of PD, belongs to a member of the ROCO protein family [29] and has five major functional domains [30]: a leucine-rich repeat (LRR); a Roc domain (Ras in complex proteins); a COR domain (C-terminal of Roc); a TyrKc domain (tyrosine kinase catalytic), and WD40 domain. The variations of LRRK2 account for approximately 5-15% of familial and sporadic PD [2].
Finally, and quite recently, the gene for PARK8 [Parkinson disease (autosomal dominant) 8] has been identified by two different groups in the gene encoding for LAAK2 (leucine-rich repeat kinase 2), a large protein containing leucine-rich repeats and Ras/GTPase, tyrosine kinase-like, and WD40 domains (Paisan-Ruiz et al.