systemic inflammatory response syndrome

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systemic inflammatory response syndrome

clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count.

systemic inflammatory response syndrome

clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count.
Farlex Partner Medical Dictionary © Farlex 2012

systemic inflammatory response syndrome

A term that 'was developed to imply a clinical response arising from a nonspecific insult and includes two or more of the following. See Sepsis, Septic shock, Severe sepsis.
Systemic inflammatory responses
Temperature < 36ºC or > 38ºC
Heart rate > 90 beats/min
Respiratory rate pCO2 < 32 mm Hg or > 20 breaths/min
WBC count < 4 x 109 or > 12 x 109 or , or the presence of > 0.10 immature neutrophils
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

systemic inflammatory response syndrome



Any severe illness characterized by a heart rate > 90 beats per min, respirations exceeding 20 breaths per minute, a PaCO2 of less than 32 mm Hg, and a white blood count greater than 12,000 cells/mL or less than 4000 cells/mL (or the presence of more than 10 percent immature (band) white blood cells. SIRS can begin with any serious illness or injury involving inflammation but is most often associated with systemic infection (sepsis) caused by gram-negative bacteria. See: sepsis; septic shock


Lipopolysaccharide endotoxins released by gram-negative and gram-positive bacteria bind with lymphocytes and endothelial cells, stimulating a cascade of cytokine release, which produces systemic inflammation of blood vessels, tissues, and organs. Shock develops when cytokines cause vasodilation and increased vascular permeability; SIRS is one of the main causes of multiple organ dysfunction syndrome.


Treatment for SIRS is focused on treating the primary cause. Multiple antibiotic therapy is required in sepsis. Supportive measures include the use of intravenous fluids and pressors, to support blood pressure, and intensive monitoring and optimization of oxygenation, ventilation, blood pressure, cardiac rhythms, serum electrolytes, and renal function.

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References in periodicals archive ?
The mean hemoglobin values, WBC counts, and platelet counts on days 1, 5, and 10 were similar between the groups receiving the original drug and the biosimilar (Table 2).
In conclusion, our results revealed that isotretinoin therapy led to a decrease in WBC count, absolute lymphocyte count, and MPV in patients with acne.
In this study frequency analysis was also performed for WBC count for positive and negative sepsis cases.
Initial Patient Laboratory Values Test Patient Value Reference Range BUN 21 mg/dL 7-19 mg/dL Creatinine 1.34 mg/dL 0.67-1.17 mg/dL AST 448 unit/L 9-37 unit/L ALT 285 unit/L 12-78 unit/L WBC count 8.1 K/mcL 4.5-13.0 K/mcL Neutrophil count 92% 40-70%
(18) found a significant relationship between increased platelet count and LNI, whereas there was no significant relationship between WBC count and LNI (19).
where ULN is the upper limit of the LDH reference range, and WBC is the WBC count per microliter (X[10.sup.6]).
The median WBC count for the AT group was 12.1x[10.sup.3]/[micro]L, OCR was 12.0x[10.sup.3]/[micro]L, and the UOC was 7.3x[10.sup.3]/[micro]L.
The WBC count gradually decreased by the tenth day of life to 24.8 x [10.sup.9]/L (Figure 1).
WBC count has been proposed and used as a prognostic marker for long.
The mean total WBC count of the blue-naped parrot is 5.96 X [10.sup.3] cells/[mm.sup.3] is comparable with both the established baseline values for total WBC count of both the African gray parrot and greater sulphur-crested cockatoo.
His lab tests (including immunophenotyping and karyotype) revealed acute monocytic leukemia (FAB M5) (WBC count = 127 x [10.sup.9]/L) and acute kidney injury.