WASF1

WASF1

A gene on chromosome 6q21 that encodes a downstream effector involved in transmitting signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. WASF1 promotes formation of actin filaments; it is part of WAVE complexes that regulate lamellipodia formation and actin filament reorganisation via its interaction with the Arp2/3 complex. It is highly expressed in the brain.
References in periodicals archive ?
Analysis of gene expression of cytoskeleton regulators indicated that short-term exposure of ASCs to 0.1% [O.sub.2] downregulated the expression of ACTR3, DSTN, MACF1, MIDI, MYPT1, NCK1, ROCK1, TIAM1, and WASF1, the products of which represent important regulators of [beta]-actin depolymerisation and lamellipodia formation.
The other components of the network (ACTR3, DSTN, MACF1, MID1, MYPT1, NKC1, TIAM1, and WASF1) are structural proteins or effectors, but are not key regulators of cell function, and their protein interactions are poorly understood.
The top one DCG identified is WASF1, which is an important gene in the Salmonella infection pathway and was not identified as a DEG (expression fold change: 1.08; t-test p value of 0.34).