CDKN1A

(redirected from WAF1)

CDKN1A

A gene on chromosome 6p21.2 that encodes a cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, thus acting as a regulator of cell cycle progression at G1. CDKN1A expression is controlled by p53, a tumour suppressor that mediates p53-dependent cell cycle G1-phase arrest in response to various stress stimuli. CDKN1A is specifically cleaved by CASP3-like caspases, activating CDK2 and possibly also the apoptosis pathway.
References in periodicals archive ?
Altered WAF1 genes do not play a role in abnormal cell cycle regulation in breast cancers lacking p53 mutations.
Clone Catalogue number Dilution Ki-67 30-9 790-4286 Ready to use p21 WAF1 DCS-60.2 790-4286 Ready to use p27Kip1 SX53G8 760-4268 Ready to use Cyclin D1 SP4-R 790-4508 Ready to use Type of antibody Ki-67 Rabbit monoclonal mouse p21 WAF1 Mouse monoclonal mouse p27Kip1 Mouse monoclonal mouse Cyclin D1 Rabbit monoclonal mouse Manufacturer Ki-67 Ventana Medical Systems; Roche Group, Tucson, USA p21 WAF1 Cell Marque, Rocklin, USA p27Kip1 Ventana Medical Systems; Roche Group, Tucson, USA Cyclin D1 Ventana Medical Systems; Roche Group, Tucson, USA Table 2: The tercile analysis for low--moderate--high-grade GIST according to Ki-67 HSPR%.
Kim, "Rosmarinic acid suppresses retinal neovascularization via cell cycle arrest with increase of p21(WAF1) expression," European Journal of Pharmacology, vol.
Ultraviolet light exposure triggers nuclear accumulation of p21 (WAF1) and accelerated senescence in human normal and nucleotide excision repair-deficient fibroblast strains.
(38) Genistein combined with docetaxel or gemcitabine significantly inhibited Bcl-2/ Bcl-xL, survivin, and induced P21 WAF1, suggesting that combination treatment regulates the important molecules in the apoptotic pathway.
We decomposed this variable into three parts, as follows: (a) frequency of accidents causing leave time (WAF1), with leave time defined as missing work for more than 24 hours (three days); (b) frequency of accidents with or without leave (WAF2), meaning all accidents requiring medical assistance, whether or not resulting in missed work time; and (c) frequency of registered accidents (WAF3), defined as all accidents, including minor ones only requiring first aid, usually provided at a nearby first aid post or at the store.
Ginsenoside-Rs 4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21 WAF1 in human hepatoma SK-HEP-1 cells.
(2008) reportan que en condiciones normales la proteina p53 es degradada por el complejo MDM2 (en ingles: Mouse Double Minute 2), pero cuando existe estres mitogenico o dano del ADN se activa la primera via de senalizacion, pues la actividad de MDM2 se suprime, originando que la proteina p53 active la proteina p21 (tambien denominada CDK-N1a, p21Cip1, Waf1 o SDI1) que es inhibidora de kinasas dependientes de ciclinas (CDKI), la cual frena el ciclo celular.
ElledgeXand Bert Vogelstein of Johns Hopkins School of Medicine in Baltimore led to the realization that Vogelstein's team also had this gene in hand, under the alias of WAF1.
Yoshida, "Laminar shear stress inhibits vascular endothelial cell proliferation by inducing cyclin-dependent kinase inhibitor p21(Sdi1/Cip1/ Waf1)," Circulation Research, vol.