Vma5 | definition of Vma5 by Medical dictionary
ATP6V1C1 (redirected from Vma5)
ATP6V1C1 A gene on chromosome 8q22.3 that encodes a subunit of H+-ATPase (also known as V-ATPase, vacuolar ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles, which is required for an array of molecular processes, including protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation.
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References in periodicals archive
V-ATPase complex integrity independent on the Ras-cAMP-PKA pathway is supported by the unaltered disassembly of the Vma5
subunit of the [V.sub.1] domain upon glucose withdrawal in ira2 mutant cells, as observed by microscopical observation of a Vma5-RFP fusion protein .
This protein is encoded by the ATP6V1C gene, also known as VATC, Vma5
, ATP6C, ATP6D, and FLJ20057, EC 184.108.40.206; it is located at position 22 on the long arm of chromosome 8 (8q22.3) (Sun-Wada et al., 2003b; Inoue and Forgac, 2005; Drory et al., 2004; Pietrement et al., 2006).