ATP6V1C1

(redirected from Vma5)

ATP6V1C1

A gene on chromosome 8q22.3 that encodes a subunit of H+-ATPase (also known as V-ATPase, vacuolar ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles, which is required for an array of molecular processes, including protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation.
References in periodicals archive ?
V-ATPase complex integrity independent on the Ras-cAMP-PKA pathway is supported by the unaltered disassembly of the Vma5 subunit of the [V.sub.1] domain upon glucose withdrawal in ira2 mutant cells, as observed by microscopical observation of a Vma5-RFP fusion protein [14].
This protein is encoded by the ATP6V1C gene, also known as VATC, Vma5, ATP6C, ATP6D, and FLJ20057, EC 3.6.3.14; it is located at position 22 on the long arm of chromosome 8 (8q22.3) (Sun-Wada et al., 2003b; Inoue and Forgac, 2005; Drory et al., 2004; Pietrement et al., 2006).