grape seed extract

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Related to Vitis vinifera: Vitis labrusca

grape seed extract

(grayp seed ex-trakt) ,

Vitis vinifera

(trade name),

Vitis coignetiae

(trade name),

Oligomeric Proanthocyanidins (OPCs)

(trade name)


Therapeutic: cardioprotective agents
Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing.


Grape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal and inhibition of collagenase.

Therapeutic effects

Reduced risk of coronary disease.
Decreased skin and vasculature breakdown.


Absorption: Unknown.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile



Contraindicated in: Hypersensitivity or allergy to grape seed extract; Patients with bleeding disorders or receiving anticoagulant therapy.
Use Cautiously in: Obstetric: Avoid use in pregnancy due to lack of safety data.

Adverse Reactions/Side Effects


  • hypertension

Central nervous system

  • dizziness
  • headache


  • dry skin

Ear, Eye, Nose, Throat

  • sore throat
  • cough


  • nausea
  • diarrhea


  • ↑ risk of bleeding


May ↑ anticoagulant effects of warfarin.May ↓ plasma levels of CYP1A2 substrates.May inhibit the growth of lactobacillus acidophilus.May ↑ BP in hypertensive patients also takingvitamin c.
Oral (Adults) 75–300 mg daily.


Tablets :

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor serum cholesterol levels periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance (Indications)


  • Administer as directed. Doses may vary.

Patient/Family Teaching

  • Advise patient not to take grape seed extract with Vitamin C; may cause increase in BP.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected.

Evaluation/Desired Outcomes

  • Decrease in cholesterol.
  • Decrease in BP.
Drug Guide, © 2015 Farlex and Partners

grape seed extract

Abbreviation: GSE
An extract of antioxidant oils isolated from the seeds of grapes (Vitis vinifera) and promoted by alternative and complementary medical practitioners as a potential treatment for coronary artery disease, cancer, and other illnesses produced or worsened by oxidative stresses on body tissues. The extract has been used as a traditional European remedy for diseases of the eyes and skin seems to reduce postoperative swelling faster than placebo. Scientific evidence for its clinical effectiveness is sparse.
See also: extract
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
In preparative purification of resveratrol from vine stems, the powdered stems of several cultivars (Vitis vinifera cv., 'Hasaine Sladki', 'Zilga', 'Jubilei Novgoroda') were mixed (total 2790 g) and macerated twice with 96.6% ethanol, 5 mL per g of the material as described above.
The accumulation of stilbene glycosides in Vitis vinifera cell suspension cultures.
COLLINS, C.; COLES, R.; CONRAN, J.G.; RAWNSLEY, B.T he progression of primary bud necrosis in the grapevine cv.Shiraz (Vitis vinifera L.): A histological analysis.
Grapevine [European (Vitis vinifera L.) or American (Vitis labrusca L.) or Muscadine (Vitis rotundifolia L.)] is one of the earliest fruit crop grown in the world (Salunkhe and Kadam, 1995).
The poise of Corrie's first-place "Words," and the brio of Greacen's second-place "Vitis vinifera," make the best kind of implicit case for the virtues of poetic form.
En las uvas de Vitis vinifera, los antocianos son monoglucosidos de malvidina, delfinidina, peonidina, petunidina o cianidina, segun las sustituciones de la molecula.
A team led by Sean Myles of Cornell, looked at 1,000 samples of the domesticated grape, Vitis vinifera subsp.
Best of the Bunch The dried fruits of Vitis vinifera.
La aclimatizacion se puede mejorar si se incrementa la concentracion de sacarosa en el medio de cultivo, debido a la produccion de biomasa durante el crecimiento in vitro, que persiste aun despues del transplante (Fila et al., 1998); tras 30 dias obtuvieron 100% en la aclimatizacion del portainjerto de Vitis vinifera 'Chasselas'xVitis berlandieri 41B, al emplear en medio con 18,3; 36,4; 73,0 y 109,6mM de sacarosa.