grape seed extract

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Related to Vitis vinifera: Vitis labrusca

grape seed extract

(grayp seed ex-trakt) ,

Vitis vinifera

(trade name),

Vitis coignetiae

(trade name),

Oligomeric Proanthocyanidins (OPCs)

(trade name)


Therapeutic: cardioprotective agents
Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing.


Grape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal and inhibition of collagenase.

Therapeutic effects

Reduced risk of coronary disease.
Decreased skin and vasculature breakdown.


Absorption: Unknown.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile



Contraindicated in: Hypersensitivity or allergy to grape seed extract; Patients with bleeding disorders or receiving anticoagulant therapy.
Use Cautiously in: Obstetric: Avoid use in pregnancy due to lack of safety data.

Adverse Reactions/Side Effects


  • hypertension

Central nervous system

  • dizziness
  • headache


  • dry skin

Ear, Eye, Nose, Throat

  • sore throat
  • cough


  • nausea
  • diarrhea


  • ↑ risk of bleeding


May ↑ anticoagulant effects of warfarin.May ↓ plasma levels of CYP1A2 substrates.May inhibit the growth of lactobacillus acidophilus.May ↑ BP in hypertensive patients also takingvitamin c.
Oral (Adults) 75–300 mg daily.


Tablets :

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor serum cholesterol levels periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance (Indications)


  • Administer as directed. Doses may vary.

Patient/Family Teaching

  • Advise patient not to take grape seed extract with Vitamin C; may cause increase in BP.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected.

Evaluation/Desired Outcomes

  • Decrease in cholesterol.
  • Decrease in BP.

grape seed extract

Abbreviation: GSE
An extract of antioxidant oils isolated from the seeds of grapes (Vitis vinifera) and promoted by alternative and complementary medical practitioners as a potential treatment for coronary artery disease, cancer, and other illnesses produced or worsened by oxidative stresses on body tissues. The extract has been used as a traditional European remedy for diseases of the eyes and skin seems to reduce postoperative swelling faster than placebo. Scientific evidence for its clinical effectiveness is sparse.
See also: extract
References in periodicals archive ?
Comparative anatomy and morphology of Vitis vinifera (Vitaceae) somatic embryos from solid and liquid culture-derived proembryogenic masses.
Diagnosis of Pierce's disease using biomarkers specific to Xylella fastidiosa rRNA and Vitis vinifera gene expression.
Throughout field prospection eight samples of Vitis vinifera branches were excised from vines exhibiting black dead arm or Eutypa diebacksymptoms.
Sin embargo, proponemos continuar realizando mas estudios sobre la germinacion in vitro a partir de semillas de Vitis vinifera L
This can be explained perhaps by a combination of factors, such as cultivated grapes, particularly Vitis vinifera, not being the preferred plant host of this leafhopper and the likely good control provided by its natural enemies, particularly egg parasitoids, which has not yet been demonstrated.
Para as duas ultimas safras, 2009 e 2010, foi feito o acompanhamento da curva de maturacao determinando-se a evolucao dos valores de solidos soluveis ([grados]Brix), acidez total, alem da analise da pigmentacao fenolica (antocianina, totais fenolicos, taninos), para a variedade de Vitis vinifera estudada.
The positive effects of osmotic potential, provoked by high sucrose concentrations in medium, on the accumulation of anthocyanins was demonstrated in cell cultures of Vitis vinifera, where an increase in osmotic potential of the medium from -0.
By working with Vitis vinifera varieties, as well as French hybrids, and a Minnesota native grape based on the Vitis riparia species, they have produced vines that are cold hardy, disease resistant, with good productivity, and with practical dates for bud break and ripening.
Best of the Bunch The dried fruits of Vitis vinifera.