grape seed extract

(redirected from Vitis coignetiae)

grape seed extract

(grayp seed ex-trakt) ,

Vitis vinifera

(trade name),

Vitis coignetiae

(trade name),

Oligomeric Proanthocyanidins (OPCs)

(trade name)


Therapeutic: cardioprotective agents
Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing.


Grape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal and inhibition of collagenase.

Therapeutic effects

Reduced risk of coronary disease.
Decreased skin and vasculature breakdown.


Absorption: Unknown.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile



Contraindicated in: Hypersensitivity or allergy to grape seed extract; Patients with bleeding disorders or receiving anticoagulant therapy.
Use Cautiously in: Obstetric: Avoid use in pregnancy due to lack of safety data.

Adverse Reactions/Side Effects


  • hypertension

Central nervous system

  • dizziness
  • headache


  • dry skin

Ear, Eye, Nose, Throat

  • sore throat
  • cough


  • nausea
  • diarrhea


  • ↑ risk of bleeding


May ↑ anticoagulant effects of warfarin.May ↓ plasma levels of CYP1A2 substrates.May inhibit the growth of lactobacillus acidophilus.May ↑ BP in hypertensive patients also takingvitamin c.
Oral (Adults) 75–300 mg daily.


Tablets :

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor serum cholesterol levels periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance (Indications)


  • Administer as directed. Doses may vary.

Patient/Family Teaching

  • Advise patient not to take grape seed extract with Vitamin C; may cause increase in BP.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected.

Evaluation/Desired Outcomes

  • Decrease in cholesterol.
  • Decrease in BP.
Drug Guide, © 2015 Farlex and Partners

grape seed extract

Abbreviation: GSE
An extract of antioxidant oils isolated from the seeds of grapes (Vitis vinifera) and promoted by alternative and complementary medical practitioners as a potential treatment for coronary artery disease, cancer, and other illnesses produced or worsened by oxidative stresses on body tissues. The extract has been used as a traditional European remedy for diseases of the eyes and skin seems to reduce postoperative swelling faster than placebo. Scientific evidence for its clinical effectiveness is sparse.
See also: extract
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Wild grape (Vitis coignetiae, VP), which is regionally planted in Japan, also generates pomace after juicing.
The soft green foliage and eye-catching flowers of clematis make them favourites for breaking up the outline of trellis fencing, while vigorous plants such as Vitis coignetiae will hide sheds or ugly walls, cloaking them in large,heart-shaped leaves which turn into a fiery mix of blood-red and yellow in autumn.
(Sapindales: Simaroubaceae), Parthenocissus quinquefolia (L.) Planchon (Vitales: Vitaceae), Vitis coignetiae Pulliat ex Planchon (Vitales: Vitaceae), and Vitis vinifera L.
There is already a magnificent vine, Vitis coignetiae, at the height of its spectacular autumn performance - its huge leaves colouring up in crimson, orange and russet.
In this study, we investigated the anthocyanins isolated from Vitis coignetiae Pulliat for their potential anti-proliferative and apoptotic effects on human colon cancer HCT-116 cells.
As well as the parthenocissus, brilliant autumn coloured climbers include ornamental vines (vitis coignetiae has large leaves that turn golden then crimson) and bittersweet (celastrus orbiculatus) is great to grow up an old tree trunk.
The flowerbeds near the house are packed with a mixture of shrubs, perennials and annuals with climbers such as Vitis coignetiae enjoying the warmth of a massive old brick wall.
Some climbers, including Hedera canariensis 'Gloire de Marengo', Jasminum officinale 'Fiona Sunrise', Hydrangea serratifolia and Vitis coignetiae need no pruning, other than to keep within your boundary.
Some climbers,including Hedera canariensis Gloire de Marengo, Jasminum officinale Fiona Sunrise, Hydrangea serratifolia and Vitis coignetiae need no pruning,other than to keep within your boundary.
When it comes to foliage, three climbers really stand out - the grape vine, Vitis vinifera, Vitis coignetiae, which has huge leaves that colour richly in the autumn, and Actinidia kolomikta, the cousin of the Kiwi fruit, whose leaves are pink, white and green, and whose small white flowers are beautifully scented.
On the same fence is a vigorous |vine, Vitis coignetiae - a magnicent sight in autumn when its huge leaves become ruby red and brilliant orange.
On the same fence is a vigorous vine, Vitis coignetiae - a magnificent sight in autumn when its huge leaves become ruby red and brilliant orange.