vindesine


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vindesine

 [vin´dĕ-sēn]
a synthetic vinca alkaloid derived from vinblastine, administered intravenously as the sulfate salt as an antineoplastic agent in the treatment of acute lymphoblastic leukemia and non–small cell carcinoma.

vin·de·sine

(vin'dĕ-sēn),
Synthetic derivative of vinblastine that shares antineoplastic properties with the latter agent; used to treat childhood lymphocytic leukemia.

vindesine

Eldisine® Oncology An experimental vinca alkaloid used to manage CA, Hodgkin's disease, leukemia, other lymphoproliferative disorders Adverse effects BM toxicity, neuropathy

vindesine

A vinca alkaloid anticancer drug (see CYTOTOXIC DRUGS) used to treat LEUKAEMIA. A brand name is Eldisine.
References in periodicals archive ?
The patient was treated with rituximab, cyclophosphamide, epirubicin, vindesine, and prednisone for 6 courses and remained in partial remission till now.
Kawahara et al., "Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer," Journal of Clinical Oncology, vol.
All but 1 patient had previously received at least 2 other treatments, including chemotherapy for 8, with dacarbazine, carboplatin, temozolomide, vindesine, fotemustine, or cyclophosphamide; vaccination for 4; anti-CTLA4 antibody ipilimumab for 2 (10 or 3mg/kg for 1 each); NCT00324155 protocol: dacarbazine (850mg/m2 every 3 weeks) + ipilimumab (10mg/kg every 3 weeks) for 2; NCT00338130 protocol comparing AstraZeneca AZD6244 versus temozolomide, radiotherapy delivered to a cutaneous metastasis on the lower limb, and surgery for small intestine resection.
In case of a lack of response to the DTIC therapy, a cisplatin (or its analogues) combined with other cytostatic drugs (carboplatin, nitrourea, taxanes, vindesine, and vinblastine) may be effective.
The patient underwent 4 cycles of chemotherapy with ABVD (doxorubicin, bleomycin, vindesine, and dacarbazine).
Neurotoxic Agents by Class Class Medications Bortezomib Cytomib[R], Velcade[R] Platinum compounds Cisplatin (Platinol[R]) Carboplatin (Paraplatin[R]) Oxaliplatin (Eloxatin[R]) Taxanes Paclitaxel (Abraxane[R], Taxol[R]) Docetaxel (Taxotere[R]) Thalidomide, lenalidomide Thalomid[R], REVLIMID[R] Vinca alkaloids Vincristine (Oncovin[R]) Vnblastine Vindesine Vinorelbine (Navelbine[R]) Source: Naleschinski et al., 2012 TABLE 3.
Invitation to tender: drugs of the l-compositions for treating malignancies (thioguanine, vinblastine, vincristine, vindesine, vinorelbine, etc.)
Well known examples include Vinca alkaloids (vincristine, vinblastine, vindesine, vinorelbine), taxanes (paclitaxel, docetaxel), epipodophyllotoxines (etoposide, teniposide), camptothecine and its derivatives (topothecan, irinothecan), and anthracydines (doxorubicin, daunorubicin, epirubicine, idarubicin).
A recent update of randomised trials conducted by the GELA group and others evaluating the efficacy of rituximab in addition to CHOP or intensified CHOP (namely, ACVBP: 75mg/[m.sup.2] doxorubicin and 1200 mg/[m.sup.2] cyclophosphamide on day 1; 2mg/[m.sup.2] vindesine and 10 mg bleomycin on days 1 and 5; and 60 mg/[m.sup.2] prednisone on days 1-5) demonstrated that the benefit of rituximab is maintained over the years [1-7].
Postoperatively, the patient underwent five courses of chemotherapy with the R-THP-CVP regimen (rituximab, pirarubicin, doxorubicin, hydrochloride, cyclophosphamide hydrate, vindesine sulfate, and prednisolone).
MVP combination Auricular acupressure 2003 [43] RCT, (mitomycin + vindesine LongHua Hospital + cisplatin) or NP Affiliated to combination (Navelbine SUTCM, Shanghai, + cisplatin) or FAM China combination (fluorouracil + Adriamycin + mitomycin), and so forth.
Combination chemotherapy with doxorubicin, bleomycin and vindesine for AIDS-related Kaposi's sarcoma.