SCN5A

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SCN5A

A gene on chromosome 3p21 that encodes an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel alpha subunit, which is expressed primarily in cardiac myocytes and is responsible beginning the action potential as seen on an ECG/EKG.
 
Molecular pathology
SCN5A mutations are long QT syndrome type 3.
References in periodicals archive ?
This cluster is made up of two varifactors (VF1,VF2) which account for 36.7% and 22.2% respectively for the total variance with a strong positive loading for CO (0.789), [O.sub.3] (0.763), [PM.sub.10] (0.768), N[O.sub.2] (0.838), ambient temperature (0.882) and wind speed (0.879).
Variables Cluster 1 Cluster 2 VF1 VF2 VF3 VF1 VF2 CO 0.776 0.27 -0.318 0.826 -0.033 O3 0.361 0.691 -0.111 0.756 0.057 PM10 0.784 -0.089 -0.073 0.663 0.061 S[O.sub.2] -0.102 0.715 0.293 0.219 0.126 N[O.sub.2] 0.767 0.006 0.211 0.81 -0.054 ABT TEMP -0.111 0.181 0.781 0.421 0.763 WIND SPEED 0.059 -0.432 0.542 -0.272 0.864 Eigenvalue 2.131 1.211 1.06 2.646 1.343 Variability (%) 30.444 17.297 15.139 37.795 19.183 Cumulative % 30.444 47.741 62.88 37.795 56.978 Variables Cluster 3 VF1 VF2 CO 0.789 -0.028 O3 0.763 0.013 PM10 0.768 0.034 S[O.sub.2] 0.262 0.01 N[O.sub.2] 0.838 -0.046 ABT TEMP 0.033 0.882 WIND SPEED -0.054 0.879 Eigenvalue 2.571 1.554 Variability (%) 36.734 22.206 Cumulative % 36.734 58.94 Table 5: Prediction performance of ML-FF-ANN model A and MLR model B.
En la zona de HP, el VF1 justifico el 48,9 % de la varianza total y tenia cargas fuertes en DQO, DBO, SST, TP, N[H.sub.4.sup.+] y N[O.sub.2.sup.-].
The agency will be headed by Tessa Gee, whose experience of working in the UK dance music and club scene at VF1 Publicity in Wolverhampton has built the platform from which 3DPR will launch.
Chris Date, aged 24, is a PR account manager for publicity company VF1. Clients include the Birmingham club Pulse's Sundissential event and Radio 1 DJ Dave Pearce.
VF1 Publicity, the Midland music and youth culture media consultancy, is moving to the historic Chubb Buildings in Wolverhampton.
VF1 advises clients in the fields from mainstream music and entertainment, to new-style dance music.
Midland pop PR agency VF1 has won a contract to represent a radio bid in Scotland.
Contractor name : ARGE HAM VF1, BA 1-5 BICKHARDT BAU AG/KREBS INFRASTRUKTUR & BETONBAU GMBH
"This is why I'm proud the Victorian Government is investing to support the operations of Flotilla VF1 at Frankston, and providing for their search and rescue vessel," Mr Armistead said.