Hepatic venoocclusive disease
following stem cell transplantation: incidence, clinical course, and outcome.
Liver injury may occur with chemotherapy regimens such as irinotecan, which may cause steatohepatitis, and oxaliplatin, which may cause nodular regenerative hyperplasia or sinusoidal obstruction syndrome (previously known as venoocclusive disease
CT features of hepatic venoocclusive disease
and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantation.
Sinusoidal obstruction syndrome (SOS), previously known as venoocclusive disease
(VOD), is a rare life-threatening condition seen most commonly after hematopoietic stem cell transplantation (HSCT).
So far, authors have implicated conditioning regimen toxicity, portal hypertension from venoocclusive disease
of the liver, thrombotic microangiopathy, and chronic graft versus host disease (GVHD).
Xenobiotic-induced liver injury is liver damage caused by pharmaceutical, chemical, herbal or nutritional agents, for example: Reye's syndrome, acetaminophen/ paracetamol-induced damage, venoocclusive disease
(VOD), total parenteral nutrition associated cholestasis19-22.
GVHD and Hepatic Venoocclusive Disease
. None of the patients in the 3 groups developed hepatic venoocclusive disease
Another study found no association between sepsis and AKI but venoocclusive disease
(VOC) and age have been shown to be risk factors for AKI in allogeneic HSCT .
Studies in patients with AML or hematopoietic progenitor cell transplants have shown that fever, sepsis, splenomegaly, disseminated intravascular coagulation (DIC), bleeding, venoocclusive disease
, graft versus host disease (GVHD), and medications can all be causes of refractoriness to platelet transfusion.
Another cause may be acute reversible hypoxemia syndrome and pulmona ry venoocclusive disease
. These in group one patients was similar but per- centage of these findings was higher than a study done by Paran D.19 A recent study done in Greece by Tzouvelekis20 showed HRCT findings such as nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonitis (UIP) pattern was about 33% in patients with APS patients.
* Venoocclusive disease
(sinusoidal obstruction syndrome)
6-Thioguanine therapy for psoriasis causing toxic hepatic venoocclusive disease
. J Am Acad Dermatol.