Venezuelan hemorrhagic fever


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Venezuelan hemorrhagic fever

a febrile disease caused by the Guanarito virus in Venezuela and characterized by headache, arthralgia, pharyngitis, leukopenia, thrombocytopenia, and hemorrhagic manifestations.

Venezuelan hemorrhagic fever

a hemorrhagic fever caused by an arenavirus transmitted to humans by contact with or inhalation of aerosolized excreta of infected rodents. The disease occurs in west central Venezuela, primarily in settlers moving into areas of cleared forest. Initially it is characterized by the gradual onset of fever, malaise, myalgia, and anorexia, followed by prostration, dizziness, headache, back pain, and GI disturbances. Bleeding of the gums is a typical finding, and there may be petechiae on the palate and axillae. Neurological manifestations, such as tremor of tongue and hands, diminished deep tendon reflexes, lethargy, and hyperesthesia, often occur. Most patients begin to improve after 1 or 2 weeks, but the disease takes a more serious course in about a third; some patients develop a hemorrhagic diathesis; some develop severe neurological deterioration marked by delirium, coma, and convulsions; and still others develop a mixed hemorrhagic-neurological syndrome with shock. Treatment is supportive, with careful attention to fluid and electrolyte balance. If untreated, the case fatality rate may reach 30% or more. With aggressive treatment, the usual prognosis is complete recovery.

Ven·e·zu·e·lan hem·or·rha·gic fe·ver

(ven'ĕ-zwā'lăn hem'ŏr-aj'ik fē'vĕr)
A febrile disease caused by the Guanarito virus in Venezuela; characterized by headache, arthralgia, pharyngitis, leukopenia, thrombocytopenia, and hemorrhagic manifestations.
References in periodicals archive ?
Description of Guanarito virus (Arenaviridae: Arenavirus), the etiologic agent of Venezuelan hemorrhagic fever.
Although Pichinde virus is not associated with human disease, Guanarito virus, which is hosted by Zygodontomys brevicauda, the short-tailed cane mouse (3,4), causes Venezuelan hemorrhagic fever in the Venezuelan state of Portuguesa (5).
These included Sable, the cause of Brazilian hemorrhagic fever, and Guanarito, the cause of Venezuelan hemorrhagic fever.
Infections and conditions requiring containment care during transport Arenavirus infection Argentine hemorrhagic fever (Junin virus) Bolivian hemorrhagic fever (Machupo virus) Brazilian hemorrhagic fever (Sabia virus) Lassa fever Venezuelan hemorrhagic fever (Guanarito virus) Bunyavirus infection Congo-Crimean hemorrhagic fever Filovirus infection Ebola Marburg Orthopoxvirus infection Monkeypox Variola Pneumonic plague until sputum cultures are negative Any unknown virulent communicable disease pending diagnosis Suspected biological-warfare--caused infection