Venezuelan equine encephalitis

Venezuelan equine encephalitis

An alphavirus infection first identified in a sick horse in Venezuela in 1938, which occurs as an epizootic infection in central and northern South America; most exposed humans develop flu-like Sx; ±4%, especially adolescents, develop encephalitis Mortality Up to 35% in the young; < 10% in adults Management Supportive. Cf Eastern equine encephalitis, Western equine encephalitis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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Venezuelan equine encephalitis virus (VEEV), western equine encephalitis virus (WEEV), and eastern equine encephalitis virus (EEEV) are nonsegmented, positive-sense RNA viruses of the genus Alphavirus in the family Togaviridae [1].
The rat is also one of the only known hosts of a particular strain of the Venezuelan equine encephalitis complex, known as the Everglades virus, which is spread by mosquitoes.
- US-based biomedical research, drug discovery and development company SRI International has been awarded two agreements worth USD 4.7m to manufacture and conduct clinical testing on a potential new vaccine against Venezuelan equine encephalitis, the company said.
The scientists used the eTXP cells isolated from human umbilical cord perivascular tissue, and engineered them by adding a gene encoding a humanized Venezuelan equine encephalitis virus (VEEV)-neutralizing antibody (anti-VEEV).
The Simplicon polycistronic RNA strand has been engineered to self-replicate over time with the addition of VEE (Venezuelan equine encephalitis virus) structural proteins (NSP1, NSP2, NSP3 and NSP4) upstream of the reprogramming factors.
In some reports mosquitoes act as potent vectors of Eastern Encephalitis Virus, Venezuelan Equine Encephalitis Virus and Western Equine Encephalitis Virus to humans through wild birds.
The blueprint of this virus, Venezuelan Equine Encephalitis, was provided by Venezuelan President Hugo Chavez in an agreement two years ago with the Islamic regime.
He then researched on brucellosis, bovine tuberculosis, rabies and Venezuelan equine encephalitis.
In this case, the genes that enable the Venezuelan equine encephalitis (VEE) virus to replicate itself were removed and replaced with genes that make the cancer biomarker carcinoembryonic antigen (CEA), which is present in many malignant colon, breast and lung cells.
Pegylated alpha interpheron is an effective treatment for virulent venezuelan equine encephalitis virus and has profound effects on the host response to infection.