vasospastic angina


Also found in: Acronyms.

vasospastic angina

chest pain caused by spasms of the coronary arteries. It has features that differ from those of angina pectoris. See also Prinzmetal's angina.
References in periodicals archive ?
Chronic inflammation is associated with vasospastic angina by increasing the number of white blood cells in the periphery, monocytes, hs-CRP, interleukin-6 and adhesion molecules (Itoh 2007; Yasue H et al 2006).
Acetylcholine, ergonovine, serotonin and histamine cause vasodilation by inducing the release of nitric oxide (NO) from the endothelial level, but its dysfunction may induce episodes of vasospastic angina (Yasue 2008).
The increase of rho-kinase activity at smooth muscle cell level directly promotes contraction by increasing the conversion of the myosin light chain in Ca 2+ and indirectly by augmenting the phosphorylation of the same chain, so that the use of a Rho-kinase inhibitor (hidroxifasudil) is able to prevent the occurrence of vasospastic angina (Hung MJ 2014).
In vasospastic angina a pathogenic role for oxidative stress is suggested by the presence of the low plasma levels of vitamin E and the elevated levels of thioredoxin (Hung MJ 2014).
Polymorphisms of several genes encoding other proteins described in vasospastic angina include adrenergic and serotonergic receptors, angiotensin-converting enzymes and inflammatory cytokines (Park et al 2006).
1 mV of the ST-segment in at least two adjacent derivatives, and the incidence of a negative U-wave, otherwise absent during the rest period, raises suspicions about a vasospastic angina (JCS Joint Working Group 2010; Hung MJ 2014).
The intravenous administration of Fasudil in patients previously treated with intracoronary nitroglycerin has further action in dilating the coronary arteries in patients with vasospastic angina (Hung MJ 2014).
Events such as coronary bypass surgery, myocardial infarction or sudden death occur in the first stages of disease development; in 76% of the patients who experience such episodes, they occurr during the first month of the onset of vasospastic angina.
With a view to the role of the coronary spasm in ischemic heart disease, the untreatable vasospastic angina was defined as the angina which cannot be controlled by two different types of coronary dilators.
Hung MJ, Cherng WJ, Hung MY et al (2012) Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina.