CDH5

(redirected from Vascular endothelial cadherin)

CDH5

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH5 is thought to play a key role in endothelial cell biology by controlling cohesion and organisation of intercellular junctions.
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In addition, CTNND1 plays a fundamental role in regulating the stability and expression of vascular endothelial cadherin (VE-cadherin), which is required for organization of endothelial cells during angiogenesis (Carmeliet and Collen, 2000; Reynolds and Carnahan, 2004; Xiao et al.
Abbreviations PA Panduratin A HUVECs human umbilical vein endothelial cells iTRAQ isobaric tags for relative and absolute quantification IPA Ingenuity Pathway Analysis mTOR mammalian target of rapamycin protein kinase VEGF vascular endothelial growth factor HIF1[alpha] hypoxia-inducible factor l[alpha] GRB-2 growth factor receptor-bound protein 2 STAB-1 stabilin-1 ICAM-2 Intercellular adhesion molecule-2 CTNND1 p120-catenin ARPC2 actin-related protein 2/3 complex subunit 2 STMN1 stathmin PI propidium iodide ANOVA one-way analysis of variance VE-cadherin vascular endothelial cadherin
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