Vascular Cell Adhesion Molecule 1 | definition of Vascular Cell Adhesion Molecule 1 by Medical dictionary
VCAM-1 (redirected from Vascular Cell Adhesion Molecule 1)
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VCAM-1 Vascular cell adhesion molecule 1. A cell-surface sialoglycoprotein encoded by VCAM1 on 1p32-p31, which belongs to the Ig superfamily, is expressed by cytokine-activated endothelium, and is involved in early inflammation. It mediates leukocyte-endothelial cell adhesion and signals transduction, recruiting monocytes and lymphocytes to the endothelial cell surface, triggering a chronic inflammatory response linked to atherosclerosis and rheumatoid arthritis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
vascular cell adhesion molecule-1,
A cell adhesion molecule that helps bind white blood cells such as lymphocytes or monocytes to the endothelium of blood vessels. Synonym: vascular cell adhesion protein
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive
Human vascular endothelial cell adhesion receptors for Plasmodium falciparum infected erythrocytes: roles for endothelial leucocytes adhesion molecule 1 and vascular cell adhesion molecule 1
. J Exp Med 1992; 176: 1183-9.
Washington, July 31 (ANI): Scientists from University of Erlangen-Nuremberg in Erlangen, Germany have revealed that measuring the level of vascular cell adhesion molecule 1
(VCAM-1) can help predict the severity of osteoarthritis.
Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1
(VCAM-1), and E-selectin through nuclear factor-KB activation in endothelial cells.