TRPV1

(redirected from Vanilloid receptor 1)

TRPV1

A gene on chromosome 17p13.2 that encodes a protein which is a receptor for capsaicin and the structurally related vanilloids, and is a non-selective cation channel structurally related to the TRP family of ion channels. The receptor is also activated by high temperatures, suggesting that it functions as a transducer of noxious chemical and painful thermal stimuli in vivo.
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The activation of the vanilloid receptor 1 by the endogenic ligand AEA leads to degeneration of dopaminergic neurons (Kim et al.
Vanilloid receptor 1 expression in the rat urinary tract.
Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons.
Vanilloid receptor 1 expression in human tooth pulp in relation to caries and pain.
Sangamo is using ZFP TFs to specifically repress the expression of three of these targets; the Vanilloid Receptor 1 (VR1), a non-selective cationic channel that responds to thermal, pH and capsacin stimulation; the Tyrosine kinase A receptor (TrkA), shown to be involved in chronic spinal cord injury, and the sodium channel Nav1.
The protein, vanilloid receptor 1 (VR1), sits on nerve cells.
Rationale for vanilloid receptor 1 antagonist-based therapies in asthma
The scientists focused on ethanol, the world's favorite form of alcohol, and its influence on a protein called the vanilloid receptor 1 (VR1).