van der Woude syndrome

(redirected from Van der Woude's syndrome)

van der Woude syndrome

(van dĕr wō'dĕ),
an autosomal recessive condition characterized by cleft lip and palate or isolated cleft palate and lip pits.
[Anne van der Woude]

van der Woude syndrome

(van dĕr wō'dĕ),
an autosomal recessive condition characterized by cleft lip and palate or isolated cleft palate and lip pits.
[Anne van der Woude]

IRF6

A gene on chromosome 1q32.3-q41 that encodes a member of the interferon regulatory transcription factor (IRF) family, which have diverse roles such as virus-mediated activation of interferons and modulation of cell growth, differentiation, apoptosis and immune system activity. IRF6 appears to be a transcription activator.

Molecular pathology
IRF6 mutations are linked to non-syndromic orofacial cleft type 6, popliteal pterygium syndrome and van der Woude syndrome.

Van der Woude syndrome

(van'der-wood?e)
An autosomal dominant syndrome marked by cleft lip, palate, or both, paramedian pits of the lower lip, hypodontia, and missing second premolar teeth. Synonym: cleft lip–cleft palate syndrome; lip-pit syndrome
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References in periodicals archive ?
Taurodontism has been reported in association with certain syndromes and some genetic defects like hy- podontia, Mohr syndrome, Down syndrome, Van der Woude's syndrome and cleft lip/palate, but its true significance is still obscure.18,19 The reported preva- lence of taurodont molars and premolars ranges from 0.25[?]11.3% (Table 1) which means that a endodontitist seeing 100 patients a week could expect an average of 5 patients a week to show features of taurodontism.
Genetic mutations have been found in MSX1; in interferon regulatory factor-6 (IRF6), a cause of Van der Woude's syndrome; and in fibroblast growth factor receptor 1 (FGFR1), which is associated with Kallmann syndrome.
Patients with Van der Woude's syndrome present with lip pits in 85% of cases.