The individuals who would benefit most from vagus nerve stimulation
therapy with the NCP are those in whom medication has failed and surgery would not, or has not, helped in controlling seizures.
Safe as add-on treatment Anticonvulsants No significant evidence Stimulants No significant evidence Glutamate Further research is needed Acetylcholine Minocycline Oxytocin Brain stimulation therapies tDCS Meta-analysis of RTCs comparing tDCS and rTMS TMS with sham interventions show that both treatments have significant efficacy VNS Further research is needed DBS DBS: deep brain stimulation; RCTs: randomized controlled trials; tDCS: transdirect current stimulation; TMS: transcranial magnetic stimulation; VNS: vagus nerve stimulation
Source: References 1-3
Muscle stimulation devices market will witness the benefits of clinical trials being conducted by healthcare universities such as the Ohio State University for curtailing the motor skills recovery time for stroke patients through vagus nerve stimulation
Electrical stimulation to the right areas may stop inflammation.7 Activation of vagus nerve modulates leukocyte cytokine production and alleviates experimental shock and autoimmune disease, recent data have suggested that vagus nerve stimulation
can improve symptoms in human rheumatoid arthritis.8 Development of a Microchannel Electrode Array (DCEA) capable of interfacing nerve fascicles as small as 50-300 micrometre.9 There appears to be the potential for an ultrasound-based neural interface system for advancing future bioelectronics-based therapies.10 The main claimed advantages of the new devices are integration of multiple steps in complex analytical procedures, diversity of application, sub-microliter consumption of reagents, sample and portability.11
Other types of treatment include brain surgery, another type of surgery called vagus nerve stimulation
, and a special diet called the ketogenic diet which is sometimes used for children.
Vagus Nerve Stimulation
also offers many advantages.
Cervical vagus nerve stimulation
(VNS) has been approved for the treatment of refractory epilepsy and depression in the Unites States.
On the other hand, low vagus nerve activity has been related to poor outcome, and vagus nerve stimulation
with a good outcome in other conditions such as irritable bowel syndrome, metabolic syndrome, diabetes, sepsis, pancreatitis, depression, pain, and epilepsy [23-29].
Vagus nerve stimulation
, or VNS, is FDA-approved for patients with chronic moderate-to-severe MDD who have not responded to repeated courses of antidepressant medication.
Behavioural and cognitive effects during vagus nerve stimulation
in children with intractable epilepsy - a randomized controlled trial.
Vagus nerve stimulation
: from pre-clinical to clinical application: challenges and future directions.