amprenavir(redirected from VX-478)
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amprenavir/am·pren·a·vir/ (am-pren´ah-vir) an HIV protease inhibitor used in the treatment of HIV-1 infection.
an antiviral (protease inhibitor).
indication It is used to treat HIV in combination with other antiretroviral agents.
contraindication Known hypersensitivity prohibits its use.
adverse effects Life-threatening side effects include Stevens-Johnson syndrome and acute hemolytic anemia. Other serious adverse effects include new-onset diabetes, hyperglycemia, and exacerbation of preexisting diabetes mellitus. Common side effects include diarrhea, abdominal pain, nausea, paresthesia, and rash.
amprenavirA protease inhibitor used with other antiretrovirals for managing HIV-1 (e.g., nelfinavir, indinavir or saquinavir).
Nausea, vomiting, diarrhoea, headache, perioral paraesthesias, gastric discomfort, rash, hyperglycaemia, diabetes, acute haemolytic anaemia, spontaneous bleeding in haemophiliacs, fat redistribution.