Of the 428 patients in whom information about underlying disease was available, commonest underlying illnesses were PUV (118, 27.6%), VUR
(85, 19.9%), neurogenic bladder (22, 5.1%), PUJO (15, 3.5%), hydronephrosis (10, 2.3%), percutaneous nephrostomy (10, 2.3%), other congenital anomalies of the urinary tract (14, 3.3%), stricture urethra (9, 2.1%), recurrent UTI (7, 1.6%), urinary tract trauma (5, 1.2%), renal stone disease (4, 0.9%), and post surgical patients (on systems other than genitourinary tract) (11, 2.6%).
The Italian researchers conducting this unblinded, randomized controlled study enrolled 100 children <2.5 years of age with VUR
grade II, III, or IV diagnosed at the first episode of pyelonephritis.
Interestingly, the profile organisms responsible for the pyelonephritis were slightly different if the woman had a history of VUR
, said Dr.
She was also informed that VUR
tends to have a strong genetic predisposition, and any future children should be screened early.
is most commonly diagnosed in infancy and childhood after the patient has a urinary tract infection (UTI).
Versagen ich den luden, soe en hain ich des winterdaichs geyn werck, Niet Tzo myn, got moiss vur
gayn," letter nr.
Although ANH resolves by birth or during infancy in 41-88% patients 1urological abnormalities requiring intervention are identified in 4.1-15.4%  and rates of vesicoureteric reflux (VUR
) and urinary tract infections (UTI) are several-fold higher.
1 Hydronephrosis is estimated to affect 14.5% of all pregnancies, albeit its significance and optimal management remains controversial.2 A wide range of disorders can account for hydronephrosis in children, such as ureteropelvic junction obstruction (UPJO), vesicoureteral reflux (VUR
), posterior urethral valves (PUV) and other pathologies.
The 2010 AUA VUR
guidelineswere also excluded as this document does not discuss management of pediatric UTI specifically.
The contralateral kidney may present with vesicourethral reflux (VUR
), uretero pelvic junction obstruction (UPJ) and ureterovesical junction obstruction (UVJ).
Vesicoureteral reflux (VUR
) is defined as the retrograde passage of urine from the bladder into the upper urinary tract .
In 16 patients (11.3%), grade 1-3 vesicoureteric reflux (VUR
) was identified but it spontaneously improved, without the need for treatment.