VSX2 | definition of VSX2 by Medical dictionary
VSX2 A gene on chromosome 14q24.3 that encodes a homeobox protein which plays a key role in the specification and morphogenesis of the sensory retina. It may participate in the development of the cells of the inner nuclear layer, particularly bipolar cells.
VSX2 mutations are associated with microphthalmia, cataracts and iris abnormalities.
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References in periodicals archive
The neural retinal epithelium was positive for retinal progenitor marker CHX10, also called VSX2
, which coexpressed with proliferative marker MCM2 (Figure 3(b)).
Mutual antagonism of the paired-type homeobox genes, vsx2
and dmbxl, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression.