Vogt-Koyanagi-Harada syndrome

(redirected from VKH disease)

Vogt-Koyanagi-Harada syndrome

 [fōkt ko-yah-nah´ge hah-rah´dah]
a syndrome of uveomeningitis associated with retinochoroidal detachment, temporary or permanent deafness and blindness, and sometimes (usually not permanent) alopecia, vitiligo, and poliosis. The etiology is unknown, but it may be an inflammatory autoimmune condition. Called also Harada syndrome.

Vogt-Koyanagi-Harada syndrome

[fōkt kō ·yah·nah′ge hah-rah′dah]
a syndrome of uveomeningitis associated with retinochoroidal detachment; temporary or permanent deafness and blindness; and, sometimes (usually not permanent), alopecia, vitiligo, and poliosis. The cause is unknown, but it may be an inflammatory autoimmune condition. Also called Harada syndrome.

Harada,

Einosuke, Japanese ophthalmologist, 1892-1947.
Harada disease - Synonym(s): Harada syndrome
Harada syndrome - bilateral retinal edema, uveitis, choroiditis, and retinal detachment, with deafness, graying of the hair, and alopecia. Synonym(s): Harada disease; uveoencephalitis; uveomeningitis syndrome
Vogt-Koyanagi-Harada syndrome - see under Vogt, Alfred

Koyanagi,

Yosizo, Japanese ophthalmologist, 1880-1954.
Vogt-Koyanagi syndrome - see under Vogt, Alfred
Vogt-Koyanagi-Harada syndrome - see under Vogt, Alfred

Vogt,

Alfred, Swiss ophthalmologist, 1879-1943.
limbal girdle of Vogt - corneal opacity that occurs in an arc concentric pattern.
Vogt-Koyanagi syndrome - bilateral uveitis with iritis and glaucoma, premature graying of the hair, alopecia, vitiligo, and dysacusia. Synonym(s): oculocutaneous syndrome; uveocutaneous syndrome
VKH syndrome - Synonym(s): Vogt-Koyanagi-Harada syndrome
Vogt-Koyanagi-Harada syndrome - systemic inflammatory eye condition. Synonym(s): VKH syndrome
References in periodicals archive ?
2,3 VKH disease is not very common, but is seen in Asian (more commonly from eastern and southeastern Asia), Middle Eastern, Hispanic, and Native American populations.
These findings are consistent with the previous data which shows that patients with VKH disease, who are diagnosed early and treated appropriately never develop any dermatologic manifestation of the disorder.
According to the "expert panel recommendations for the use of anti-TNF[alpha] drugs in patients with ocular inflammatory disorders, " the use of infliximab (IFX, Inflectra, Pfizer) or adalimumab (ADA, Humira, Abbvie) may be considered in VKH disease patients intolerant or unresponsive to traditional immunosuppressive therapies (3).
A review of all the patients diagnosed with VKH disease being evaluated from the uveitis unit of one tertiary hospital was carried out from January 1, 2000, to October 30, 2015.
9) Because choroid thickness increases in both VKH disease and CSCR, noninvasive EDI-OCT examination is not useful for differentiating between these two entities.
In conclusion, bullous type CSCR may be confused with ocular symptoms of acute VKH disease.
This phenotype also found in patient with VKH disease.
Although the etiology of VKH disease has yet to be elucidated, several studies have suggested that it is a cell-mediated autoimmune disorder in which cytotoxic T cells target melanocytes.
Herein, we present a case of VKH disease associated with RA.
Ocular infiltrating CD4+ T cells from patients with VKH disease recognize human melanocyte antigens," Invest.
The complete and incomplete forms of VKH disease are more frequent than the probable form.
VKH disease consists of a nonnecrotizing diffuse granulomatous inflammation of the uveal tractus.