En el estudio VITATOPS
(Vitamins To Prevent Stroke) (68), los resultados publicados basados en el efecto de la terapia con vitamina B en la poblacion total estudiada proporcionan una estimacion limitada del "efecto real" una vez que se alcanza la reduccion de homocisteina como objetivo.
B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: the VITAmins TO Prevent Stroke (VITATOPS
Saposnik, "The role of vitamin B in stroke prevention: a journey from observational studies to clinical trials and critique of the VITAmins TO Prevent Stroke (VITATOPS
)," Stroke, vol.
The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS
, a randomised placebo-controlled trial.
Vitalicious sells frozen VitaMuffin VitaTops
in a variety of flavors.
Daily B vitamin supplementation !is no more effective than is placebo for reducing the incidence of major vascular events in patients who have had a recent stroke or transient ischemic attack, according to findings from the Vitamins to Prevent Stroke (VITATOPS
Daily B vitamin supplementation is no more effective than is placebo for reducing the incidence of major vascular events in patients who have had a recent stroke or transient ischemic attack, according to findings from the Vitamins to Prevent Stroke (VITATOPS
For a better choice, check out Vitalicious 100-calorie whole-grain VitaMuffins and VitaTops
, which come in more than a dozen varieties like Dark Chocolate Pomegranate, Deep Chocolate, Banana Nut, AppleBerry, Banana Fudge, and BlueBran.
, the little 100-calorie snack cakes pack 6 grams of fiber and 0.4 grams of plant sterols.
The folks at New York-based Vitalicious are having better luck with their new VitaMuffin VitaTops
. Each two-ounce, individually wrapped VitaTop
contains only 100 calories, is fat free, and is a good source of both soluble and insoluble fiber.
In the VITATOPS
trial, 8164 patients with a recent stroke or transient ischemic attack were -randomly assigned to receive, in double-blind fashion, placebo or daily B vitamins (2 mg of folic acid, 25 mg vitamin B6, and 500 mcg vitamin B12) and were followed up for a median 3.4 years.
Due to be completed within the next 1-2 years are two major ongoing randomized trials: the Australian VITAmins TO Prevent Stroke (VITATOPS
) study, featuring 8,000 patients with recent stroke or transient ischemic attack, and the Oxford University-based Study of the Effectivess of Additional Reductions In Cholesterol and Homocysteine (SEARCH) trial in more than 12,000 patients with various forms of occlusive vascular disease.