FLT1

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FLT1

A gene on chromosome 13q12 that encodes a member of the vascular endothelial growth factor receptor (VEGFR) family of receptor tyrosine kinases (RTKs), which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment and a tyrosine kinase (TK) domain within the cytoplasmic domain. FLT1 binds to VEGFR-A, VEGFR-B and placental growth factor, plays an important role in angiogenesis and is expressed in vascular endothelial cells, placental trophoblast cells and monocytes.
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Given VEGFR-1 is the receptor for VEGF-B; this study also confirmed expression of VEGFR1 in mouse spinal cord by RT-PCR analysis of VEGFR-1 transcript levels.
Similarly, db/db mice with VEGFR1 inhibition, which enhanced VEGFR-2 activity, showed prominent albuminuria and mesangial expansion together with a loss of podocytes and endothelial cells [54].
Tambien, estarian involucrados otros genes, como el receptor del VEGF tirosinaquinasa parecido al fms-1 (VEGFR1 = fms-like tyrosine kinase1) y el factor de crecimiento placentario (PIGF), presentes en las rutas angiogenicas.
ABSTRACT The effects of nitrous oxide on vascular endothelial growth factor (VEGF) and its soluble receptor 1 (VEGFR1) in patient undergoing urological surgery
The VEGF and its receptors VEGFR1 and VEGFR2 are leading players in angiogenesis [100].
VEGF signaling occurs by binding to various cellular receptors such as VEGFR1 (FLT1), VEGFR2 (FLK1), and VEGFR3 (FLT4) [63, 64] and neuropilin-1 [65] and -2 (NRP1 and NRP2) [66] and heparan sulfate proteoglycans (HSPG) [67].
Synthesized cDNA was used as a template for quantitative polymerase chain reaction (PCR) assays using TaqMan Universal PCR Master Mix (Life Technologies), AmpErase UNG (Life Technologies), and TaqMan probes [FGFR1 (Hs 00241111), FGFR2 (Hs 01552926), FGFR3 (Hs 00179829), FGFR4 (Hs 00242558), VEGFR1 (Hs 01904119), VEGFR2 (Hs 00176676), VEGFR3 (Hs 01047687), KIT (Hs 00174029), EGFR (Hs 00193306), PDGFRA (Hs 00183486), PDGFRB (Hs 00182163), MET (Hs 01565580), RET (Hs 01120032), 18S rRNA (Hs 99999901)] (Life Technologies, Carlsbad, CA) in an ABI 7900 PCR system (Life Technologies).
Jain, "Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells," PLoS ONE, vol.4, no.
The VEGF family ligands bind to tyrosine kinase receptors VEGFR1, VEGFR2, and VEGFR3 (Figure 1), each receptor containing an extracellular domain of approximately 750 amino acid residues, arranged within seven immunoglobulin-like folds [10].
Sorafenib's targets include the serine/threonine kinases c-Raf and B-Raf, the receptor tyrosine kinases RET, Flt-3, and c-Kit, and receptor tyrosine kinases important in tumor angiogenesis, including the vascular endothelial growth factor receptor family (VEGFR1, -2, and -3) and platelet-derived growth factor-beta [8].
Este factor de crecimiento, que puede ser producido y secretado por el musculo esqueletico, se une principalmente a dos receptores, ubicados en las celulas endoteliales, VEGFR1 y VEGFR2 (48-50) (tabla 1).