It can be estimated, based on the results from our lab, that low [K.sub.m] value for ADP can be a common characteristic for cancer cells grown in culture, but in in vivo tumor samples, the regulation of MOM permeability is more complicated and probably related to interplay between energy transfer pathways and changes in the phosphorylation state of VDAC
channels [32, 104-107] and also with modulation of cytoskeleton or membrane potential as a result of tumor formation.
We next determined whether either of these two proteins (VDAC
or GRP78) was acting as JEV receptor proteins through antibody inhibition experiments.
Dreier, "Voltage-dependent anion channels (VDACs
) recruit Parkin to defective mitochondria to promote mitochondrial autophagy," The Journal of Biological Chemistry, vol.
The steady-state levels of ADP and ATP reflect well-known diffusion restrictions for adenine nucleotides (see for review Vendelin et al., 2004, 2007) for passing through the mitochondrial porin channel (VDAC
) as well the absence of these restrictions for PCr--which should reach the cellular cytoplasm.
Influenza virus PB l-F2 protein induces cell death through mitochondrial ANT3 and VDAC
Abreviaturas: [DELTA][[psi]m, potencial de membrana mitocondrial; ANT, transportador de nudeotidos de adenosina; EA, enfermedad de Alzheimer; EP enfermedad de Parkinson; EPCR, receptores endoteliales de proteina C; HSP, proteinas de choque termico; IkB, inhibidor kappa B; mPTP, poro de permeabilidad transicional mitocondrial; NFkB factor nuclear kappa B; PAR-l, receptor-1 activado por proteasa; PCA, proteina C activada; SN, sustancia nigra; TNE factor de necrosis tumoral; VDAC
, canal anionico dependiente de voltaje.
Isolation and characterization of the mitochondrial channel, VDAC
, from the insect Heliothis virescens.
For example, Fu and Qutubuddin (29) prepared end-tethered PNC with PS matrix by pre-intercalating MMT with vinyl-benzyl-dimethyl dodecyl ammonium chloride (VDAC
), dispersing it in styrene and copolymerizing, XRD and TEM of the samples indicated full exfoliation.
EXCEL HAS UPGRADED its EXS media gateway with the addition of the new voice data access concentrator (VDAC
Then, Parkin ubiquitinates OMM proteins, such as voltage-dependent anion channel (VDAC
) 1, generating polyubiquitin chains via Lys27, so that recruits LC3-interacting region- (LIR-) containing autophagy receptors, such as sequestosome (p62/SQSTM), which simultaneously binds to LC3, pointing to the mitochondria that should be eliminated [13, 18].
Whereas Bcl-xl is the most potent anti-apoptotic protein in colon cancer cells by occupying the binding site of Bax (Ming et al., 2006) and blocking the permeability transition pore via binding to voltage-dependent anion channel l(VDAC
) (Arbel et al., 2012).