VCAN


Also found in: Acronyms.

VCAN

A gene on chromosome 5q14.3 that encodes an aggrecan/versican proteoglycan, which is a large chondroitin sulphate and major component of the extracellular matrix involved in cell adhesion, proliferation, migration and angiogenesis, and which plays a central role in tissue morphogenesis and maintenance.

Molecular pathology
VCAN mutations cause Wagner syndrome type 1.
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An upregulation of VCAN was also observed after 7, 14, 21, and 28 days of chondrogenic stimulation (Figure 3(a)), while no amplification was detected for mRNA corresponding to COL2A1 and ACAN (Figure 3(a)).
VCAN mRNA showed a light time-dependent upregulation, while the expression of ACAN mRNA was significantly increased up to 21 and 28 days of chondrogenic differentiation (Figure 3(b)).
In the DPMSCs, while the transcription factor SOX9 and VCAN had an increase of expression, there was no expression of COL2A1 and ACAN.
The instrumented reference implementation of the hypervisor allowed to measure the execution times with respect to a virtual driver (vCan), a virtual interface (vCanIf and the physical driver (CAN).
Another important system for the interior of Northeast Brazil is VCANs which form over the South Atlantic Ocean and have an impact near the coast of Northeast Brazil.
In the A3 area, corresponding to eastern Northeast Brazil, the presence of VCANs is also observed; however, their influence depends largely on the location of the center of the vortex.
But if you book quick you vcan do the same journey by "standard" for pounds 100 for two - a good deal.
Developmental genes such as Bcan, Fbln2, Itih3, Ncam1, Tnr, and Vcan modulate NSC differentiation via Wnt/[beta]-catenin pathway at early stage of differentiation and TGF-[beta] signaling pathway at later (7 day) stage.