The integrin VLA-4 supports tethering and rolling in flow on VCAM-1
. J Cell Biol 1995;128:1243-53.
The gene expression pattern of pro and anti-inflammatory mediators, documented here after the LDE-MTX treatment by comparison with the controls, is highly suggestive that the novel preparation acts through inhibition of pro-inflammatory factors, such as TNF-[alpha], IL-18, VCAM-1
and MCP-1 and stimulation of the gene expression of anti-inflammatory factors such as IL-10.
CerbB2 was negative in the cases with negative ICAM-1 whereas estrogen receptor and progesterone receptor were positive in the cases with positive VCAM-1
CIHH treatment increased the expression of VLA-4, VCAM-1
, and ICAM-1 in BMMSCs of AA rats but decreased the expression of CD162 and CD164.
Treatment of HUVECs with anti-RAGE antibody for 24 h significantly suppressed the upregulation of RAGE, HMGB1, ICAM-1, and VCAM-1
(Figures 4(c) and 4(d)), prevented the increase in DNA binding activity of NF-[kappa]B (Figure 4(e)), and decreased the release of IL-6 and TNF-[alpha] induced by 20 mg/dL UA (Figure 4(f)).
Standardized curcuminoid extract (SCE) has the ability to protect HUVECs from vascular inflammation by suppressing LPS-induced expression of NF-[kappa]B, toll like receptor-4 (TLR-4), I CAM-1 and VCAM-1
(Angel-Morales et al.
The serum level of VCAM-1
marker in control patients was significantly increased compared to the baseline level, at the end of study (670.4 [+ or -] 68.6 [micro]g/L vs.
In particular the phosphorylation of p65 subunit at serine 276 phosphorylation regulates the expression of different types of genes including vascular cell adhesion molecule-1(VCAM-1
) and Interleukin-8(IL-8) which plays a crucial role in tumor-associated angiogenesis and metastasis.
Vascular cell adhesion molecule 1 (VCAM-1
) was measured using Quantikine ELISA Human sVCAM-1/CD106 Immunoessay (R&D Systems, Inc., United Kingdom).
Cell adhesion molecules (CAMs)--intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1
) and E-selectin are endothelial stress markers involved in the early atherosclerotic processes [1, 2].
En SD se ha observado una mayor expresion de moleculas de adhesion en celulas endoteliales, eritrocitos y linfocitos, tales como la molecula de adhesion intracelular 1 (ICAM-1) y la molecula de adhesion vascular 1 (VCAM-1
), asi como la P-selectina y la E-selectina, moleculas que interactuan con sus respectivos receptores en eritrocitos, leucocitos y plaquetas, lo que induce su adhesion al endotelio (23).
ICAM-1 and VCAM-1
are immunoglobulin superfamily of endothelial cell adhesion molecules which are important for leukocyte transmigration from within blood vessel into extravascular site of inflammatory process.