SOST

(redirected from VBCH)
Also found in: Acronyms.

SOST

A gene on chromosome17q11.2 that encodes sclerostin, a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.

Molecular pathology
Loss-of-function mutations in SOST are linked to sclerosteosis; a deletion downstream of SOST causes reduced sclerostin expression, resulting in a milder sclerosteosis (van Buchem disease).