VAV3

VAV3

A gene on chromosome 1p13.3 that encodes a member of the VAV guanine nucleotide exchange factor (GEF) family of genes. VAV3 is GEF for the Rho family of Ras-related GTPases, and plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
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Observations made by a graph in the TV2 or TV3 format of the VAV2.0 or VAV3.0 standard (one file may contain more than one mining interval)
SNPs that are present in other autoimmune diseases, such as rs6679677 near PTPN22, rs3184504 in SH2B3, and rs2517532 in HLA class I region, are linked to HT, while rs4915077 near VAV3 [20] and other SNPs such as rs7850258, rs965513, rs925489, and rs10759944, all located near FOXE1 in chromosome 9, exhibit genome-wide significance with primary HT [18].
Pathology Genes Orofacial clefts CL/P BMP4 CRISPLD2 FGF8 FGFR1 FGFR2 FOXE1 GLI2 GSTM1 GSTT1 JAG2 LHX8 MSX1 MSX1 MSX2 NAT1 NAT2 PTCH PVRL1 RYK SATB2 SKI SPRY2 TBX10 TGFB3 ATM Papillary thyroid cancer NKX2 RET (RET/PTC rearrangement) DFNB31 Hypothyroidism PTPN22 SH2B3 VAV3
genes with circadian orthologs Integrin-mediated cell PDPK1, VAV3, MAP2K5, PXN, BRAF, et al.
When taken together, two DNA Markers--methylation of the vav guanine nucleotide exchange factor 3 (VAV3) and zinc finger protein 682 (ZNF682) genes--were 100% specific and 100% sensitive for Barrett's esophagus, with an AUC of 1.0.
6A, Vavl was not found in MDA-MB-231 cells; Vav3 showed a lower expression, while Vav2 expression was in greatest abundance.
The three mammalian Vav proteins (Vavl, 2, 3) differ in their tissue distribution; Vavl is expressed predominantly in hematopoietic cells, whereas Vav2 and Vav3 are more broadly expressed.
The VAV3 or VAV1 guanine nucleotide exchange factors may be a direct substrate for phosphorylation/activation by NPMALK or be indirectly phosphorylated by the NPM-ALK-associated adaptor molecules GRB2 and p130CAS.
Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.