VAV2

VAV2

A gene on chromosome 9q34.1 that encodes a member of the VAV guanine nucleotide exchange factor (GEF) family of genes which is only expressed in haematopoietic cells. VAV2 is the GEF for the Rho family of Ras-related GTPases, and plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
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Using FDR p < 0.05, six enriched pathways were identified including "Notch Signaling Pathway" (genes NOTCH4 and DVL2), "Rlio GTPase cycle" {FAM 13A; HMHA1; VAV2; and GMIP), "Neurotransmitter Release Cycle" (HSPA8; and RIMS1), and "GABA synthesis, release, reuptake and degradation" (HSPA8; and RIMS1).
Observations made by a graph in the TV2 or TV3 format of the VAV2.0 or VAV3.0 standard (one file may contain more than one mining interval)
They also highlighted the trophic proteins, including surface receptors (e.g., PDG-FRB, EGFR, and PLAUR), signaling molecules (e.g., MAPK1, CDC42, RRAS/NRAS, and VAV2), and cell adhesion (e.g., EZR, FN1, IQGAP1, CD47, integrins, and LGALS1/ LGALS3) and MSC-associated proteins (e.g., CD9, CD63, CD81, CD109, CD151, CD248, and CD276).
Li et al., "MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42," Hepatology, vol.
Diosgenin also has antimetastatic effects; for example, it was demonstrated that it can inhibit the migration of human breast cancer MDA-MB-231 cells, at least partially, by suppressing Vav2 protein activity [42].
(95) In most cases, the increased Rac1 activity correlated with increased tyrosine phosphorylation of the Rac GEF Vav2 induced by EGFR, but an alternative pathway used Ras activation.
Li, "Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats," Hypertension, vol.
Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.
Diferentes proteinas interactuan con el dominio citoplasmatico formando un complejo de union que se activa en forma de cascada, p120 e Vav2, Shceb catenina, b cateninaea catenina, a cateninaeafadina, b cateninaeIQGAP.
Whereas Rac activation and subsequent CLAN formation is triggered by the association of Shc, Grb2, and SOS as described above, studies in human choriocarcinoma cells have found that TGF-[beta] uses Src-mediated phosphorylation to activate Vav2, a Rho-specific GEF [46, 63].
We also found diosgenin significantly inhibited actin polymerization, Vav2 phosphorylation and Cdc42 activation, which might be, at least in part, attributed to the anti-metastatic potential of diosgenin.
The initial study by Thompson et al (307) found that ALK+ ALCL overexpresses genes encoding signal transduction molecules such as SYK, LYN, and CDC37 and underexpresses transcription factors such as HOXC6 and HOXA3; both ALK+ and ALK- ALCL highly express kinase genes (LCK, protein kinase C, VAV2, and NKIAMRE) and antiapoptotic molecules.