VAV2

VAV2

A gene on chromosome 9q34.1 that encodes a member of the VAV guanine nucleotide exchange factor (GEF) family of genes which is only expressed in haematopoietic cells. VAV2 is the GEF for the Rho family of Ras-related GTPases, and plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
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Observations made by a graph in the TV2 or TV3 format of the VAV2.
PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP.
The initial study by Thompson et al (307) found that ALK+ ALCL overexpresses genes encoding signal transduction molecules such as SYK, LYN, and CDC37 and underexpresses transcription factors such as HOXC6 and HOXA3; both ALK+ and ALK- ALCL highly express kinase genes (LCK, protein kinase C, VAV2, and NKIAMRE) and antiapoptotic molecules.