Phase II study of selumetinib (sel) versus temozolomide (TMZ) in gnaq/Gna11 (Gq/11) mutant (mut) uveal melanoma
Some groups suggest (21,22) that monosomy 3 is a primary event in the developmental pathway of high-risk uveal melanoma
, and it may start as a monoclonal event, whereas over time, more clones with monosomy 3 can develop, or the primary clone may show a growth advantage compared with other cells.
Upon FDA approval, orphan drug designation entitles Hana Biosciences to seven years of market exclusivity for Marqibo(r) (vincristine sulfate injection, OPTISOME(tm)) in the treatment of adult patients with metastatic uveal melanoma
Thomas Vogl, Frankfurt University Hospital and was a retrospective evaluation of non-resectable hepatic metastases from uveal melanoma
in 14 patients treated with CHEMOSAT between 2012 and 2014.
Frequent somatic mutations of GNAQ in uveal melanoma
and blue naevi.
They found that there was no statistically significant link between mobile phone use of up to about 10 years and uveal melanoma
A comparative analysis of uveal melanoma
has indicated that five-year mortality rates after enucleation were 16% for small, 32% for medium and 53% for large tumours.
Patients with uveal melanoma
may present with complaints of visual loss, but many are without symptoms and the condition is discovered on routine ocular examination.
is a cancer arising from melanocytes located in the uveal tract.
Collaboration Based on New Data Published by UCSF Team in Journal Nature Describing the Role of Mutated GNAQ in the Development of Uveal Melanoma
Candidate prognostic indicators have included features found to be significant in cutaneous melanoma (eg, tumor thickness, histologic type, mitotic activity), or less frequently, in uveal melanoma
(ie, cytologic type, the mean of the 10 largest nucleoli, extravascular matrix patterning, or microvascular density).
The Martin Luther-University of Halle-Wittenberg examined the association between phone use and risk of uveal Olelanoma in 459 patients and 1,194 cotrol subjects and found there was no statistically significant association between mobile phone use of up to about ten years and uveal melanoma