is a rare and aggressive form of melanoma, which affects the eye, typically has a poor prognosis and for which there is no currently accepted optimal management or treatment.
Role of epigenetics in uveal melanoma
. Int J Biol Sci 2017;13:426-33.
. A tumor response was observed in 4 patients (3.6%; 95% CI: 1.0-9.0%) treated with chemotherapy (including 2 patients with complete response and 2 patients with partial response) and in no patient treated with immunotherapy (0%; 95% CI: 0.0-3.6%).
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and Fanconi anaemia," Oncogene, vol.
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: histopathologic findings," Ophthalmology, vol.
Our patient with this metastatic uveal melanoma
with extensive liver metastases with GNQ-209P mutation on the tissue biopsy (Figures 3 and 4) and undetectable mutations on the peripheral blood molecular profiling in serial follow-up samples suggests marked response to nabpaclitaxel.
Dr Christina Coughlin, chief medical officer at Immunocore, commented on the data: "We are excited to share these data in advanced uveal melanoma
is the most common malignant intraocular tumor in adults, which accounts for 3.7% of all melanoma cases.
Murali, "BAP1 protein loss by immunohistochemistry: a potentially useful tool for prognostic prediction in patients with uveal melanoma
," Pathology, vol.
Seddon et al., "Survival of patients with metastases from uveal melanoma
," Ophthalmology, vol.
Servois et al., "Pyrophosphorolysis-activated polymerization detects circulating tumor DNA in metastatic uveal melanoma
," Clinical Cancer Research, vol.
is the most common primary intraocular malignancy in adults.